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Predictive Factors of Clinical Response of Infliximab Therapy in Active Nonradiographic Axial Spondyloarthritis Patients
Joint Authors
Li, Qiuxia
Huang, Jianlin
Wei, Qiujing
Cao, Shuangyan
Liao, Zetao
Lin, Zhiming
Pan, Yunfeng
Li, Tianwang
Jin, Ou
Ai, Maixing
Wu, Henglian
Lu, Jun
Li, Li
Tang, Deshen
Wei, Yanlin
Wu, Yuqiong
Xu, Manlong
Yu, Buyun
Gu, Jieruo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
To evaluate the efficiency and the predictive factors of clinical response of infliximab in active nonradiographic axial spondyloarthritis patients.
Methods.
Active nonradiographic patients fulfilling ESSG criteria for SpA but not fulfilling modified New York criteria were included.
All patients received infliximab treatment for 24 weeks.
The primary endpoint was ASAS20 response at weeks 12 and 24.
The abilities of baseline parameters and response at week 2 to predict ASAS20 response at weeks 12 and 24 were assessed using ROC curve and logistic regression analysis, respectively.
Results.
Of 70 axial SpA patients included, the proportions of patients achieving an ASAS20 response at weeks 2, 6, 12, and 24 were 85.7%, 88.6%, 87.1%, and 84.3%, respectively.
Baseline MRI sacroiliitis score (AUC = 0.791; P = 0.005 ), CRP (AUC = 0.75; P = 0.017 ), and ASDAS (AUC = 0.778, P = 0.007 ) significantly predicted ASAS20 response at week 12.
However, only ASDAS (AUC = 0.696, P = 0.040 ) significantly predicted ASAS20 response at week 24.
Achievement of ASAS20 response after the first infliximab infusion was a significant predictor of subsequent ASAS20 response at weeks 12 and 24 (wald χ 2 = 6.87 , P = 0.009 , and wald χ 2 = 5.171 , P = 0.023 ).
Conclusions.
Infliximab shows efficiency in active nonradiographic axial spondyloarthritis patients.
ASDAS score and first-dose response could help predicting clinical efficacy of infliximab therapy in these patients.
American Psychological Association (APA)
Lin, Zhiming& Liao, Zetao& Huang, Jianlin& Ai, Maixing& Pan, Yunfeng& Wu, Henglian…[et al.]. 2015. Predictive Factors of Clinical Response of Infliximab Therapy in Active Nonradiographic Axial Spondyloarthritis Patients. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057108
Modern Language Association (MLA)
Lin, Zhiming…[et al.]. Predictive Factors of Clinical Response of Infliximab Therapy in Active Nonradiographic Axial Spondyloarthritis Patients. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1057108
American Medical Association (AMA)
Lin, Zhiming& Liao, Zetao& Huang, Jianlin& Ai, Maixing& Pan, Yunfeng& Wu, Henglian…[et al.]. Predictive Factors of Clinical Response of Infliximab Therapy in Active Nonradiographic Axial Spondyloarthritis Patients. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057108
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057108