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Improving the Understanding of Pathogenesis of Human Papillomavirus 16 via Mapping Protein-Protein Interaction Network
المؤلفون المشاركون
Li, Menglong
Li, Yizhou
Dong, Yongcheng
Kuang, Qifan
Dai, Xu
Li, Rong
Wu, Yiming
Leng, Weijia
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-15
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The human papillomavirus 16 (HPV16) has high risk to lead various cancers and afflictions, especially, the cervical cancer.
Therefore, investigating the pathogenesis of HPV16 is very important for public health.
Protein-protein interaction (PPI) network between HPV16 and human was used as a measure to improve our understanding of its pathogenesis.
By adopting sequence and topological features, a support vector machine (SVM) model was built to predict new interactions between HPV16 and human proteins.
All interactions were comprehensively investigated and analyzed.
The analysis indicated that HPV16 enlarged its scope of influence by interacting with human proteins as much as possible.
These interactions alter a broad array of cell cycle progression.
Furthermore, not only was HPV16 highly prone to interact with hub proteins and bottleneck proteins, but also it could effectively affect a breadth of signaling pathways.
In addition, we found that the HPV16 evolved into high carcinogenicity on the condition that its own reproduction had been ensured.
Meanwhile, this work will contribute to providing potential new targets for antiviral therapeutics and help experimental research in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dong, Yongcheng& Kuang, Qifan& Dai, Xu& Li, Rong& Wu, Yiming& Leng, Weijia…[et al.]. 2015. Improving the Understanding of Pathogenesis of Human Papillomavirus 16 via Mapping Protein-Protein Interaction Network. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057122
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dong, Yongcheng…[et al.]. Improving the Understanding of Pathogenesis of Human Papillomavirus 16 via Mapping Protein-Protein Interaction Network. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1057122
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dong, Yongcheng& Kuang, Qifan& Dai, Xu& Li, Rong& Wu, Yiming& Leng, Weijia…[et al.]. Improving the Understanding of Pathogenesis of Human Papillomavirus 16 via Mapping Protein-Protein Interaction Network. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057122
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057122
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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