Improving the Understanding of Pathogenesis of Human Papillomavirus 16 via Mapping Protein-Protein Interaction Network
Joint Authors
Li, Menglong
Li, Yizhou
Dong, Yongcheng
Kuang, Qifan
Dai, Xu
Li, Rong
Wu, Yiming
Leng, Weijia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The human papillomavirus 16 (HPV16) has high risk to lead various cancers and afflictions, especially, the cervical cancer.
Therefore, investigating the pathogenesis of HPV16 is very important for public health.
Protein-protein interaction (PPI) network between HPV16 and human was used as a measure to improve our understanding of its pathogenesis.
By adopting sequence and topological features, a support vector machine (SVM) model was built to predict new interactions between HPV16 and human proteins.
All interactions were comprehensively investigated and analyzed.
The analysis indicated that HPV16 enlarged its scope of influence by interacting with human proteins as much as possible.
These interactions alter a broad array of cell cycle progression.
Furthermore, not only was HPV16 highly prone to interact with hub proteins and bottleneck proteins, but also it could effectively affect a breadth of signaling pathways.
In addition, we found that the HPV16 evolved into high carcinogenicity on the condition that its own reproduction had been ensured.
Meanwhile, this work will contribute to providing potential new targets for antiviral therapeutics and help experimental research in the future.
American Psychological Association (APA)
Dong, Yongcheng& Kuang, Qifan& Dai, Xu& Li, Rong& Wu, Yiming& Leng, Weijia…[et al.]. 2015. Improving the Understanding of Pathogenesis of Human Papillomavirus 16 via Mapping Protein-Protein Interaction Network. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057122
Modern Language Association (MLA)
Dong, Yongcheng…[et al.]. Improving the Understanding of Pathogenesis of Human Papillomavirus 16 via Mapping Protein-Protein Interaction Network. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1057122
American Medical Association (AMA)
Dong, Yongcheng& Kuang, Qifan& Dai, Xu& Li, Rong& Wu, Yiming& Leng, Weijia…[et al.]. Improving the Understanding of Pathogenesis of Human Papillomavirus 16 via Mapping Protein-Protein Interaction Network. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057122
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057122