Preoperative Neutrophil-to-Lymphocyte Ratio and Neutrophilia Are Independent Predictors of Recurrence in Patients with Localized Papillary Renal Cell Carcinoma

المؤلفون المشاركون

Huang, Jiwei
Dahl, Douglas M.
Dong, Liang
Liu, Qiang
Cornejo, Kristine
Wang, Qi
Wu, Shulin
Feldman, Adam S.
Huang, Yiran
Xue, Wei
Wu, Chin-Lee

المصدر

BioMed Research International

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-09-03

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

Objective.

To evaluate the role of preoperative neutrophil-to-lymphocyte ratio (NLR) and absolute neutrophil count (ANC) in patients’ prognosis with localized papillary renal cell carcinoma (pRCC).

Methods.

Data from 218 localized pRCC patients (T1-3 N0/+ M0), operated between 1991 and 2011 at two centers, were evaluated retrospectively.

Univariable and multivariable analyses using the Cox regression model were performed to determine the associations of NLR and ANC with recurrence-free survival (RFS).

Prognostic accuracy was evaluated with the Harrell concordance index.

Results.

The 5-year RFS rate was 87.0%.

Multivariable analysis identified increased NLR (≥3.6) and ANC (≥5300/μL) as independent prognostic factors for RFS (hazard ratio (HR) = 4.01, P = 0.018 ) and (HR = 4.71, P = 0.045 ).

The final model built by the addition of NLR or ANC improved predictive accuracy (c-index: 0.824, 0.842) compared with the clinicopathological base model (c-index: 0.800), which included TNM stage and tumor necrosis.

Conclusions.

The NLR and ANC appear to be independent prognostic factors for RFS after surgery for localized pRCC.

They significantly increase the accuracy of established prognostic factors.

Therefore, we recommend adding NLR and ANC to traditional prognostic model, which may improve its predictive accuracy.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Huang, Jiwei& Dahl, Douglas M.& Dong, Liang& Liu, Qiang& Cornejo, Kristine& Wang, Qi…[et al.]. 2015. Preoperative Neutrophil-to-Lymphocyte Ratio and Neutrophilia Are Independent Predictors of Recurrence in Patients with Localized Papillary Renal Cell Carcinoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057125

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Huang, Jiwei…[et al.]. Preoperative Neutrophil-to-Lymphocyte Ratio and Neutrophilia Are Independent Predictors of Recurrence in Patients with Localized Papillary Renal Cell Carcinoma. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057125

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Huang, Jiwei& Dahl, Douglas M.& Dong, Liang& Liu, Qiang& Cornejo, Kristine& Wang, Qi…[et al.]. Preoperative Neutrophil-to-Lymphocyte Ratio and Neutrophilia Are Independent Predictors of Recurrence in Patients with Localized Papillary Renal Cell Carcinoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057125

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1057125