Preoperative Neutrophil-to-Lymphocyte Ratio and Neutrophilia Are Independent Predictors of Recurrence in Patients with Localized Papillary Renal Cell Carcinoma
Joint Authors
Huang, Jiwei
Dahl, Douglas M.
Dong, Liang
Liu, Qiang
Cornejo, Kristine
Wang, Qi
Wu, Shulin
Feldman, Adam S.
Huang, Yiran
Xue, Wei
Wu, Chin-Lee
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To evaluate the role of preoperative neutrophil-to-lymphocyte ratio (NLR) and absolute neutrophil count (ANC) in patients’ prognosis with localized papillary renal cell carcinoma (pRCC).
Methods.
Data from 218 localized pRCC patients (T1-3 N0/+ M0), operated between 1991 and 2011 at two centers, were evaluated retrospectively.
Univariable and multivariable analyses using the Cox regression model were performed to determine the associations of NLR and ANC with recurrence-free survival (RFS).
Prognostic accuracy was evaluated with the Harrell concordance index.
Results.
The 5-year RFS rate was 87.0%.
Multivariable analysis identified increased NLR (≥3.6) and ANC (≥5300/μL) as independent prognostic factors for RFS (hazard ratio (HR) = 4.01, P = 0.018 ) and (HR = 4.71, P = 0.045 ).
The final model built by the addition of NLR or ANC improved predictive accuracy (c-index: 0.824, 0.842) compared with the clinicopathological base model (c-index: 0.800), which included TNM stage and tumor necrosis.
Conclusions.
The NLR and ANC appear to be independent prognostic factors for RFS after surgery for localized pRCC.
They significantly increase the accuracy of established prognostic factors.
Therefore, we recommend adding NLR and ANC to traditional prognostic model, which may improve its predictive accuracy.
American Psychological Association (APA)
Huang, Jiwei& Dahl, Douglas M.& Dong, Liang& Liu, Qiang& Cornejo, Kristine& Wang, Qi…[et al.]. 2015. Preoperative Neutrophil-to-Lymphocyte Ratio and Neutrophilia Are Independent Predictors of Recurrence in Patients with Localized Papillary Renal Cell Carcinoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057125
Modern Language Association (MLA)
Huang, Jiwei…[et al.]. Preoperative Neutrophil-to-Lymphocyte Ratio and Neutrophilia Are Independent Predictors of Recurrence in Patients with Localized Papillary Renal Cell Carcinoma. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057125
American Medical Association (AMA)
Huang, Jiwei& Dahl, Douglas M.& Dong, Liang& Liu, Qiang& Cornejo, Kristine& Wang, Qi…[et al.]. Preoperative Neutrophil-to-Lymphocyte Ratio and Neutrophilia Are Independent Predictors of Recurrence in Patients with Localized Papillary Renal Cell Carcinoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057125
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057125