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African Flora Has the Potential to Fight Multidrug Resistance of Cancer
المؤلفون المشاركون
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-24، 24ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-15
دولة النشر
مصر
عدد الصفحات
24
التخصصات الرئيسية
الملخص EN
Background.
Continuous efforts from scientists of diverse fields are necessary not only to better understand the mechanism by which multidrug-resistant (MDR) cancer cells occur, but also to boost the discovery of new cytotoxic compounds to fight MDR phenotypes.
Objectives.
The present review reports on the contribution of African flora in the discovery of potential cytotoxic phytochemicals against MDR cancer cells.
Methodology.
Scientific databases such as PubMed, ScienceDirect, Scopus, Google Scholar, and Web of Knowledge were used to retrieve publications related to African plants, isolated compounds, and drug resistant cancer cells.
The data were analyzed to highlight cytotoxicity and the modes of actions of extracts and compounds of the most prominent African plants.
Also, thresholds and cutoff points for the cytotoxicity and modes of action of phytochemicals have been provided.
Results.
Most published data related to the antiproliferative potential of African medicinal plants were from Cameroon, Egypt, Nigeria, or Madagascar.
The cytotoxicity of phenolic compounds isolated in African plants was generally much better documented than that of terpenoids and alkaloids.
Conclusion.
African flora represents an enormous resource for novel cytotoxic compounds.
To unravel the full potential, efforts should be strengthened throughout the continent, to meet the challenge of a successful fight against MDR cancers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kuete, Victor& Efferth, Thomas. 2015. African Flora Has the Potential to Fight Multidrug Resistance of Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-24.
https://search.emarefa.net/detail/BIM-1057216
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kuete, Victor& Efferth, Thomas. African Flora Has the Potential to Fight Multidrug Resistance of Cancer. BioMed Research International No. 2015 (2015), pp.1-24.
https://search.emarefa.net/detail/BIM-1057216
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kuete, Victor& Efferth, Thomas. African Flora Has the Potential to Fight Multidrug Resistance of Cancer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-24.
https://search.emarefa.net/detail/BIM-1057216
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057216
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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