African Flora Has the Potential to Fight Multidrug Resistance of Cancer
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-24, 24 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-15
Country of Publication
Egypt
No. of Pages
24
Main Subjects
Abstract EN
Background.
Continuous efforts from scientists of diverse fields are necessary not only to better understand the mechanism by which multidrug-resistant (MDR) cancer cells occur, but also to boost the discovery of new cytotoxic compounds to fight MDR phenotypes.
Objectives.
The present review reports on the contribution of African flora in the discovery of potential cytotoxic phytochemicals against MDR cancer cells.
Methodology.
Scientific databases such as PubMed, ScienceDirect, Scopus, Google Scholar, and Web of Knowledge were used to retrieve publications related to African plants, isolated compounds, and drug resistant cancer cells.
The data were analyzed to highlight cytotoxicity and the modes of actions of extracts and compounds of the most prominent African plants.
Also, thresholds and cutoff points for the cytotoxicity and modes of action of phytochemicals have been provided.
Results.
Most published data related to the antiproliferative potential of African medicinal plants were from Cameroon, Egypt, Nigeria, or Madagascar.
The cytotoxicity of phenolic compounds isolated in African plants was generally much better documented than that of terpenoids and alkaloids.
Conclusion.
African flora represents an enormous resource for novel cytotoxic compounds.
To unravel the full potential, efforts should be strengthened throughout the continent, to meet the challenge of a successful fight against MDR cancers.
American Psychological Association (APA)
Kuete, Victor& Efferth, Thomas. 2015. African Flora Has the Potential to Fight Multidrug Resistance of Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-24.
https://search.emarefa.net/detail/BIM-1057216
Modern Language Association (MLA)
Kuete, Victor& Efferth, Thomas. African Flora Has the Potential to Fight Multidrug Resistance of Cancer. BioMed Research International No. 2015 (2015), pp.1-24.
https://search.emarefa.net/detail/BIM-1057216
American Medical Association (AMA)
Kuete, Victor& Efferth, Thomas. African Flora Has the Potential to Fight Multidrug Resistance of Cancer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-24.
https://search.emarefa.net/detail/BIM-1057216
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057216