Risk Factors and Scoring System for Predicting Bacterial Resistance to Cefepime as Used Empirically in Haematology Wards
المؤلفون المشاركون
Mikdame, M.
El Maaroufi, Hicham
Goubard, Agathe
Redjoul, Rabah
Legrand, Patrick
Pautas, Cécile
Toma, Andréa
Maury, Sébastien
Schwarzinger, Michael
Cordonnier, Catherine
Doghmi, K.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objectives.
Bacterial resistance is of growing concern in haematology wards.
As the inappropriate administration of empirical antibacterial may alter survival, we studied risk factors for resistance to our usual empirical first-line antibacterial therapy, cefepime.
Methods.
We retrospectively studied 103 first episodes of bacteraemia recorded in our haematology department over 2.5 years.
Risk factors for cefepime-resistance were identified by multivariate logistic regression with backward selection (P<0.05).
A scoring system for predicting cefepime-resistance was built on independent factor, with an internal validation by the bootstrap resampling technique.
Results.
38 (37%) episodes were due to Gram-negative bacteria.
Fifty (49%) were due to bacteria resistant to cefepime.
Cefepime resistance was significantly associated with a decreased survival at day 30 (P<0.05).
Three risk factors were independently associated with cefepime-resistance: acute lymphoblastic leukaemia; ≥18 days since hospital admission; and receipt of any β-lactam in the last month.
Patients with ≥2 of these risk factors had a probability of 86% (CI 95%, 25 to 100%) to carry a cefepime-resistant strain.
Conclusion.
Using our scoring system should reduce the indication of very broad antibacterial regimens in the empirical, first-line treatment of febrile hematology patients in more than 80% of the cases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
El Maaroufi, Hicham& Goubard, Agathe& Redjoul, Rabah& Legrand, Patrick& Pautas, Cécile& Mikdame, M.…[et al.]. 2015. Risk Factors and Scoring System for Predicting Bacterial Resistance to Cefepime as Used Empirically in Haematology Wards. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057336
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
El Maaroufi, Hicham…[et al.]. Risk Factors and Scoring System for Predicting Bacterial Resistance to Cefepime as Used Empirically in Haematology Wards. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057336
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
El Maaroufi, Hicham& Goubard, Agathe& Redjoul, Rabah& Legrand, Patrick& Pautas, Cécile& Mikdame, M.…[et al.]. Risk Factors and Scoring System for Predicting Bacterial Resistance to Cefepime as Used Empirically in Haematology Wards. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057336
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057336
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر