Risk Factors and Scoring System for Predicting Bacterial Resistance to Cefepime as Used Empirically in Haematology Wards

Joint Authors

Mikdame, M.
El Maaroufi, Hicham
Goubard, Agathe
Redjoul, Rabah
Legrand, Patrick
Pautas, Cécile
Toma, Andréa
Maury, Sébastien
Schwarzinger, Michael
Cordonnier, Catherine
Doghmi, K.

Source

BioMed Research International

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-05-05

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Abstract EN

Objectives.

Bacterial resistance is of growing concern in haematology wards.

As the inappropriate administration of empirical antibacterial may alter survival, we studied risk factors for resistance to our usual empirical first-line antibacterial therapy, cefepime.

Methods.

We retrospectively studied 103 first episodes of bacteraemia recorded in our haematology department over 2.5 years.

Risk factors for cefepime-resistance were identified by multivariate logistic regression with backward selection (P<0.05).

A scoring system for predicting cefepime-resistance was built on independent factor, with an internal validation by the bootstrap resampling technique.

Results.

38 (37%) episodes were due to Gram-negative bacteria.

Fifty (49%) were due to bacteria resistant to cefepime.

Cefepime resistance was significantly associated with a decreased survival at day 30 (P<0.05).

Three risk factors were independently associated with cefepime-resistance: acute lymphoblastic leukaemia; ≥18 days since hospital admission; and receipt of any β-lactam in the last month.

Patients with ≥2 of these risk factors had a probability of 86% (CI 95%, 25 to 100%) to carry a cefepime-resistant strain.

Conclusion.

Using our scoring system should reduce the indication of very broad antibacterial regimens in the empirical, first-line treatment of febrile hematology patients in more than 80% of the cases.

American Psychological Association (APA)

El Maaroufi, Hicham& Goubard, Agathe& Redjoul, Rabah& Legrand, Patrick& Pautas, Cécile& Mikdame, M.…[et al.]. 2015. Risk Factors and Scoring System for Predicting Bacterial Resistance to Cefepime as Used Empirically in Haematology Wards. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057336

Modern Language Association (MLA)

El Maaroufi, Hicham…[et al.]. Risk Factors and Scoring System for Predicting Bacterial Resistance to Cefepime as Used Empirically in Haematology Wards. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057336

American Medical Association (AMA)

El Maaroufi, Hicham& Goubard, Agathe& Redjoul, Rabah& Legrand, Patrick& Pautas, Cécile& Mikdame, M.…[et al.]. Risk Factors and Scoring System for Predicting Bacterial Resistance to Cefepime as Used Empirically in Haematology Wards. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057336

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1057336