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Epoetin Alpha and Epoetin Zeta: A Comparative Study on Stimulation of Angiogenesis and Wound Repair in an Experimental Model of Burn Injury
المؤلفون المشاركون
Bitto, Alessandra
Buemi, Michele
Pizzino, Gabriele
Irrera, Natasha
Vaccaro, Mario
Galeano, Mariarosaria
Stagno d’Alcontres, Francesco
Stagno d’Alcontres, Ferdinando
Colonna, Michele Rosario
Minutoli, Letteria
Squadrito, Francesco
Altavilla, Domenica
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-04
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Deep second-degree burns are characterized by delayed formation of granulation tissue and impaired angiogenesis.
Erythropoietin (EPO) is able to stimulate angiogenesis and mitosis, activating vascularization and cell cycle.
The aim of our study was to investigate whether two biosimilar recombinant human erythropoietins, EPO-α and EPO-Z, may promote these processes in an experimental model of burn injury.
A total of 84 mice were used and a scald burn was produced on the back after shaving, in 80°C water for 10 seconds.
Mice were then randomized to receive EPO-α (400 units/kg/day/sc) or EPO-Z (400 units/kg/day/sc) or their vehicle (100 μL/day/sc 0.9% NaCl solution).
After 12 days, both EPO-α and EPO-Z increased VEGF protein expression.
EPO-α caused an increased cyclin D1/CDK6 and cyclin E/CDK2 expression compared with vehicle and EPO-Z ( p <0.001 ).
Our study showed that EPO-α and EPO-Z accelerated wound closure and angiogenesis; however EPO-α resulted more effectively in achieving complete skin regeneration.
Our data suggest that EPO-α and EPO-Z are not biosimilars for the wound healing effects.
The higher efficacy of EPO-α might be likely due to its different conformational structure leading to a more efficient cell proliferation and skin remodelling.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Irrera, Natasha& Bitto, Alessandra& Pizzino, Gabriele& Vaccaro, Mario& Squadrito, Francesco& Galeano, Mariarosaria…[et al.]. 2015. Epoetin Alpha and Epoetin Zeta: A Comparative Study on Stimulation of Angiogenesis and Wound Repair in an Experimental Model of Burn Injury. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057429
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Irrera, Natasha…[et al.]. Epoetin Alpha and Epoetin Zeta: A Comparative Study on Stimulation of Angiogenesis and Wound Repair in an Experimental Model of Burn Injury. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057429
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Irrera, Natasha& Bitto, Alessandra& Pizzino, Gabriele& Vaccaro, Mario& Squadrito, Francesco& Galeano, Mariarosaria…[et al.]. Epoetin Alpha and Epoetin Zeta: A Comparative Study on Stimulation of Angiogenesis and Wound Repair in an Experimental Model of Burn Injury. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057429
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057429
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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