Epoetin Alpha and Epoetin Zeta: A Comparative Study on Stimulation of Angiogenesis and Wound Repair in an Experimental Model of Burn Injury
Joint Authors
Bitto, Alessandra
Buemi, Michele
Pizzino, Gabriele
Irrera, Natasha
Vaccaro, Mario
Galeano, Mariarosaria
Stagno d’Alcontres, Francesco
Stagno d’Alcontres, Ferdinando
Colonna, Michele Rosario
Minutoli, Letteria
Squadrito, Francesco
Altavilla, Domenica
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Deep second-degree burns are characterized by delayed formation of granulation tissue and impaired angiogenesis.
Erythropoietin (EPO) is able to stimulate angiogenesis and mitosis, activating vascularization and cell cycle.
The aim of our study was to investigate whether two biosimilar recombinant human erythropoietins, EPO-α and EPO-Z, may promote these processes in an experimental model of burn injury.
A total of 84 mice were used and a scald burn was produced on the back after shaving, in 80°C water for 10 seconds.
Mice were then randomized to receive EPO-α (400 units/kg/day/sc) or EPO-Z (400 units/kg/day/sc) or their vehicle (100 μL/day/sc 0.9% NaCl solution).
After 12 days, both EPO-α and EPO-Z increased VEGF protein expression.
EPO-α caused an increased cyclin D1/CDK6 and cyclin E/CDK2 expression compared with vehicle and EPO-Z ( p <0.001 ).
Our study showed that EPO-α and EPO-Z accelerated wound closure and angiogenesis; however EPO-α resulted more effectively in achieving complete skin regeneration.
Our data suggest that EPO-α and EPO-Z are not biosimilars for the wound healing effects.
The higher efficacy of EPO-α might be likely due to its different conformational structure leading to a more efficient cell proliferation and skin remodelling.
American Psychological Association (APA)
Irrera, Natasha& Bitto, Alessandra& Pizzino, Gabriele& Vaccaro, Mario& Squadrito, Francesco& Galeano, Mariarosaria…[et al.]. 2015. Epoetin Alpha and Epoetin Zeta: A Comparative Study on Stimulation of Angiogenesis and Wound Repair in an Experimental Model of Burn Injury. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057429
Modern Language Association (MLA)
Irrera, Natasha…[et al.]. Epoetin Alpha and Epoetin Zeta: A Comparative Study on Stimulation of Angiogenesis and Wound Repair in an Experimental Model of Burn Injury. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057429
American Medical Association (AMA)
Irrera, Natasha& Bitto, Alessandra& Pizzino, Gabriele& Vaccaro, Mario& Squadrito, Francesco& Galeano, Mariarosaria…[et al.]. Epoetin Alpha and Epoetin Zeta: A Comparative Study on Stimulation of Angiogenesis and Wound Repair in an Experimental Model of Burn Injury. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057429
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057429