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Targeted Mutation of Nuclear Bone Morphogenetic Protein 2 Impairs Secondary Immune Response in a Mouse Model
المؤلفون المشاركون
Bridgewater, Laura C.
Olsen, Daniel S.
Goar, Wesley A.
Nichols, Brandt A.
Bailey, K. Tyson
Christensen, S. Loyd
Merriam, Kayla R.
Reynolds, Paul R.
Wilson, Eric
Weber, K. Scott
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-23
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
We recently identified a nuclear variant of the BMP2 growth factor, called nBMP2.
In an effort to understand the function of this variant protein, we generated a mouse line in which BMP2 is expressed and functions normally, but nBMP2 is excluded from the nucleus.
This novel mutation allows the study of nBMP2 without compromising BMP2 function.
To determine whether nBMP2 plays a role in immune function, we performed a series of experiments in which we compared mouse survival, organ weights, immune cells numbers, and bacterial load in wild type and n B m p 2 N L S t m mice following primary and secondary challenges with Staphylococcus aureus.
Following primary challenge with S.
aureus, wild type and n B m p 2 N L S t m mice showed no differences in survival or bacterial load and generated similar numbers and types of leukocytes, although mutant spleens were smaller than wild type.
Secondary bacterial challenge with S.
aureus, however, produced differences in survival, with increased mortality seen in n B m p 2 N L S t m mice.
This increased mortality corresponded to higher levels of bacteremia in n B m p 2 N L S t m mice and to a reduced enlargement of mutant spleens in response to the secondary infection.
Together, these results suggest that the recently described nuclear variant of BMP2 is necessary for efficient secondary immune responses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Olsen, Daniel S.& Goar, Wesley A.& Nichols, Brandt A.& Bailey, K. Tyson& Christensen, S. Loyd& Merriam, Kayla R.…[et al.]. 2015. Targeted Mutation of Nuclear Bone Morphogenetic Protein 2 Impairs Secondary Immune Response in a Mouse Model. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1057458
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Olsen, Daniel S.…[et al.]. Targeted Mutation of Nuclear Bone Morphogenetic Protein 2 Impairs Secondary Immune Response in a Mouse Model. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1057458
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Olsen, Daniel S.& Goar, Wesley A.& Nichols, Brandt A.& Bailey, K. Tyson& Christensen, S. Loyd& Merriam, Kayla R.…[et al.]. Targeted Mutation of Nuclear Bone Morphogenetic Protein 2 Impairs Secondary Immune Response in a Mouse Model. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1057458
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057458
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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