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Concordance of Hypermethylated DNA and the Tumor Markers CA 15-3, CEA, and TPA in Serum during Monitoring of Patients with Advanced Breast Cancer
المؤلفون المشاركون
Kristiansen, Søren
Jørgensen, Lars Mønster
Hansen, Morten Høgh
Nielsen, Dorte
Sölétormos, György
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-03
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The serological protein tumor markers CA 15-3, CEA, and TPA are frequently used to monitor tumor burden among metastatic breast cancer patients.
Breast cancer is associated with global DNA hypomethylation and hypermethylation of some promoter regions.
No monitoring study has yet investigated the interrelationship between protein tumor markers, the global DNA hypomethylation, and hypermethylated genes in serum from patients with advanced disease.
Twenty-nine patients with histologically proven advanced breast cancer received first-line chemotherapy with epirubicin.
Samples were collected prior to each treatment and prospectively analyzed for CA 15-3, CEA, and TPA.
The same samples were retrospectively analyzed for the concentration of hypermethylated RASSF1A and for global DNA hypomethylation using LINE-1.
Among patients with elevated concentrations of the protein markers, concordance could be observed between serial changes of the hypermethylated RASSF1A gene and the protein markers.
Among patients with lower concentrations, RASSF1A could only be detected periodically.
There was discordance between changes of the hypomethylated LINE-1 as compared to the protein markers.
Circulating hypermethylated RASSF1A and protein markers may have similar kinetics during monitoring of tumor burden.
Further investigations are needed to determine whether any of the hypermethylated DNA genes may provide predictive information during monitoring.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kristiansen, Søren& Jørgensen, Lars Mønster& Hansen, Morten Høgh& Nielsen, Dorte& Sölétormos, György. 2015. Concordance of Hypermethylated DNA and the Tumor Markers CA 15-3, CEA, and TPA in Serum during Monitoring of Patients with Advanced Breast Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057491
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kristiansen, Søren…[et al.]. Concordance of Hypermethylated DNA and the Tumor Markers CA 15-3, CEA, and TPA in Serum during Monitoring of Patients with Advanced Breast Cancer. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1057491
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kristiansen, Søren& Jørgensen, Lars Mønster& Hansen, Morten Høgh& Nielsen, Dorte& Sölétormos, György. Concordance of Hypermethylated DNA and the Tumor Markers CA 15-3, CEA, and TPA in Serum during Monitoring of Patients with Advanced Breast Cancer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057491
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057491
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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