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Concordance of Hypermethylated DNA and the Tumor Markers CA 15-3, CEA, and TPA in Serum during Monitoring of Patients with Advanced Breast Cancer
Joint Authors
Kristiansen, Søren
Jørgensen, Lars Mønster
Hansen, Morten Høgh
Nielsen, Dorte
Sölétormos, György
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The serological protein tumor markers CA 15-3, CEA, and TPA are frequently used to monitor tumor burden among metastatic breast cancer patients.
Breast cancer is associated with global DNA hypomethylation and hypermethylation of some promoter regions.
No monitoring study has yet investigated the interrelationship between protein tumor markers, the global DNA hypomethylation, and hypermethylated genes in serum from patients with advanced disease.
Twenty-nine patients with histologically proven advanced breast cancer received first-line chemotherapy with epirubicin.
Samples were collected prior to each treatment and prospectively analyzed for CA 15-3, CEA, and TPA.
The same samples were retrospectively analyzed for the concentration of hypermethylated RASSF1A and for global DNA hypomethylation using LINE-1.
Among patients with elevated concentrations of the protein markers, concordance could be observed between serial changes of the hypermethylated RASSF1A gene and the protein markers.
Among patients with lower concentrations, RASSF1A could only be detected periodically.
There was discordance between changes of the hypomethylated LINE-1 as compared to the protein markers.
Circulating hypermethylated RASSF1A and protein markers may have similar kinetics during monitoring of tumor burden.
Further investigations are needed to determine whether any of the hypermethylated DNA genes may provide predictive information during monitoring.
American Psychological Association (APA)
Kristiansen, Søren& Jørgensen, Lars Mønster& Hansen, Morten Høgh& Nielsen, Dorte& Sölétormos, György. 2015. Concordance of Hypermethylated DNA and the Tumor Markers CA 15-3, CEA, and TPA in Serum during Monitoring of Patients with Advanced Breast Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057491
Modern Language Association (MLA)
Kristiansen, Søren…[et al.]. Concordance of Hypermethylated DNA and the Tumor Markers CA 15-3, CEA, and TPA in Serum during Monitoring of Patients with Advanced Breast Cancer. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1057491
American Medical Association (AMA)
Kristiansen, Søren& Jørgensen, Lars Mønster& Hansen, Morten Høgh& Nielsen, Dorte& Sölétormos, György. Concordance of Hypermethylated DNA and the Tumor Markers CA 15-3, CEA, and TPA in Serum during Monitoring of Patients with Advanced Breast Cancer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057491
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057491