Recent Advances in Methamphetamine Neurotoxicity Mechanisms and Its Molecular Pathophysiology

المؤلفون المشاركون

Yu, Shaobin
Zhu, Ling
Shen, Qiang
Bai, Xue
Di, Xuhui

المصدر

Behavioural Neurology

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-03-12

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الأحياء
الطب البشري

الملخص EN

Methamphetamine (METH) is a sympathomimetic amine that belongs to phenethylamine and amphetamine class of psychoactive drugs, which are widely abused for their stimulant, euphoric, empathogenic, and hallucinogenic properties.

Many of these effects result from acute increases in dopamine and serotonin neurotransmission.

Subsequent to these acute effects, METH produces persistent damage to dopamine and serotonin release in nerve terminals, gliosis, and apoptosis.

This review summarized the numerous interdependent mechanisms including excessive dopamine, ubiquitin-proteasome system dysfunction, protein nitration, endoplasmic reticulum stress, p53 expression, inflammatory molecular, D3 receptor, microtubule deacetylation, and HIV-1 Tat protein that have been demonstrated to contribute to this damage.

In addition, the feasible therapeutic strategies according to recent studies were also summarized ranging from drug and protein to gene level.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Yu, Shaobin& Zhu, Ling& Shen, Qiang& Bai, Xue& Di, Xuhui. 2015. Recent Advances in Methamphetamine Neurotoxicity Mechanisms and Its Molecular Pathophysiology. Behavioural Neurology،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1057501

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Yu, Shaobin…[et al.]. Recent Advances in Methamphetamine Neurotoxicity Mechanisms and Its Molecular Pathophysiology. Behavioural Neurology No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1057501

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Yu, Shaobin& Zhu, Ling& Shen, Qiang& Bai, Xue& Di, Xuhui. Recent Advances in Methamphetamine Neurotoxicity Mechanisms and Its Molecular Pathophysiology. Behavioural Neurology. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1057501

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1057501