Recent Advances in Methamphetamine Neurotoxicity Mechanisms and Its Molecular Pathophysiology
Joint Authors
Yu, Shaobin
Zhu, Ling
Shen, Qiang
Bai, Xue
Di, Xuhui
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Methamphetamine (METH) is a sympathomimetic amine that belongs to phenethylamine and amphetamine class of psychoactive drugs, which are widely abused for their stimulant, euphoric, empathogenic, and hallucinogenic properties.
Many of these effects result from acute increases in dopamine and serotonin neurotransmission.
Subsequent to these acute effects, METH produces persistent damage to dopamine and serotonin release in nerve terminals, gliosis, and apoptosis.
This review summarized the numerous interdependent mechanisms including excessive dopamine, ubiquitin-proteasome system dysfunction, protein nitration, endoplasmic reticulum stress, p53 expression, inflammatory molecular, D3 receptor, microtubule deacetylation, and HIV-1 Tat protein that have been demonstrated to contribute to this damage.
In addition, the feasible therapeutic strategies according to recent studies were also summarized ranging from drug and protein to gene level.
American Psychological Association (APA)
Yu, Shaobin& Zhu, Ling& Shen, Qiang& Bai, Xue& Di, Xuhui. 2015. Recent Advances in Methamphetamine Neurotoxicity Mechanisms and Its Molecular Pathophysiology. Behavioural Neurology،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1057501
Modern Language Association (MLA)
Yu, Shaobin…[et al.]. Recent Advances in Methamphetamine Neurotoxicity Mechanisms and Its Molecular Pathophysiology. Behavioural Neurology No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1057501
American Medical Association (AMA)
Yu, Shaobin& Zhu, Ling& Shen, Qiang& Bai, Xue& Di, Xuhui. Recent Advances in Methamphetamine Neurotoxicity Mechanisms and Its Molecular Pathophysiology. Behavioural Neurology. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1057501
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057501