Are Absence Epilepsy and Nocturnal Frontal Lobe Epilepsy System Epilepsies of the SleepWake System?

المؤلف

Halász, Péter

المصدر

Behavioural Neurology

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-15، 15ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-06-14

دولة النشر

مصر

عدد الصفحات

15

التخصصات الرئيسية

الأحياء
الطب البشري

الملخص EN

System epilepsy is an emerging concept interpreting major nonlesional epilepsies as epileptic dysfunctions of physiological systems.

I extend here the concept of reflex epilepsy to epilepsies linked to input dependent physiological systems.

Experimental and clinical reseach data were collected to create a coherent explanation of underlying pathomechanism in AE and NFLE.

We propose that AE should be interpreted as epilepsy linked to the corticothalamic burst-firing mode of NREM sleep, released by evoked vigilance level oscillations characterized by reactive slow wave response.

In the genetic variation of NFLE the ascending cholinergic arousal system plays an essential role being in strong relationship with a gain mutation of the nicotinic acethylcholin receptors, rendering the arousal system hyperexcitable.

I try to provide a more unitary interpretation for the variable seizure manifestation integrating them as different degree of pathological arosuals and alarm reactions.

As a supporting hypothesis the similarity between arousal parasomnias and FNLE is shown, underpinned by overlaping pathomechanism and shared familiarity, but without epileptic features.

Lastly we propose that both AE and NFLE are system epilepsies of the sleep-wake system representing epileptic disorders of the antagonistic sleep/arousal network.

This interpretation may throw new light on the pathomechanism of AE and NFLE.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Halász, Péter. 2015. Are Absence Epilepsy and Nocturnal Frontal Lobe Epilepsy System Epilepsies of the SleepWake System?. Behavioural Neurology،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1057513

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Halász, Péter. Are Absence Epilepsy and Nocturnal Frontal Lobe Epilepsy System Epilepsies of the SleepWake System?. Behavioural Neurology No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1057513

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Halász, Péter. Are Absence Epilepsy and Nocturnal Frontal Lobe Epilepsy System Epilepsies of the SleepWake System?. Behavioural Neurology. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1057513

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1057513