Are Absence Epilepsy and Nocturnal Frontal Lobe Epilepsy System Epilepsies of the SleepWake System?
Author
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-14
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
System epilepsy is an emerging concept interpreting major nonlesional epilepsies as epileptic dysfunctions of physiological systems.
I extend here the concept of reflex epilepsy to epilepsies linked to input dependent physiological systems.
Experimental and clinical reseach data were collected to create a coherent explanation of underlying pathomechanism in AE and NFLE.
We propose that AE should be interpreted as epilepsy linked to the corticothalamic burst-firing mode of NREM sleep, released by evoked vigilance level oscillations characterized by reactive slow wave response.
In the genetic variation of NFLE the ascending cholinergic arousal system plays an essential role being in strong relationship with a gain mutation of the nicotinic acethylcholin receptors, rendering the arousal system hyperexcitable.
I try to provide a more unitary interpretation for the variable seizure manifestation integrating them as different degree of pathological arosuals and alarm reactions.
As a supporting hypothesis the similarity between arousal parasomnias and FNLE is shown, underpinned by overlaping pathomechanism and shared familiarity, but without epileptic features.
Lastly we propose that both AE and NFLE are system epilepsies of the sleep-wake system representing epileptic disorders of the antagonistic sleep/arousal network.
This interpretation may throw new light on the pathomechanism of AE and NFLE.
American Psychological Association (APA)
Halász, Péter. 2015. Are Absence Epilepsy and Nocturnal Frontal Lobe Epilepsy System Epilepsies of the SleepWake System?. Behavioural Neurology،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1057513
Modern Language Association (MLA)
Halász, Péter. Are Absence Epilepsy and Nocturnal Frontal Lobe Epilepsy System Epilepsies of the SleepWake System?. Behavioural Neurology No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1057513
American Medical Association (AMA)
Halász, Péter. Are Absence Epilepsy and Nocturnal Frontal Lobe Epilepsy System Epilepsies of the SleepWake System?. Behavioural Neurology. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1057513
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057513