Identifying Novel Candidate Genes Related to Apoptosis from a Protein-Protein Interaction Network
المؤلفون المشاركون
Wang, Baoman
Hu, Lan-Dian
Cai, Yu-Dong
Yuan, Fei
Kong, Xiangyin
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-04
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Apoptosis is the process of programmed cell death (PCD) that occurs in multicellular organisms.
This process of normal cell death is required to maintain the balance of homeostasis.
In addition, some diseases, such as obesity, cancer, and neurodegenerative diseases, can be cured through apoptosis, which produces few side effects.
An effective comprehension of the mechanisms underlying apoptosis will be helpful to prevent and treat some diseases.
The identification of genes related to apoptosis is essential to uncover its underlying mechanisms.
In this study, a computational method was proposed to identify novel candidate genes related to apoptosis.
First, protein-protein interaction information was used to construct a weighted graph.
Second, a shortest path algorithm was applied to the graph to search for new candidate genes.
Finally, the obtained genes were filtered by a permutation test.
As a result, 26 genes were obtained, and we discuss their likelihood of being novel apoptosis-related genes by collecting evidence from published literature.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Baoman& Yuan, Fei& Kong, Xiangyin& Hu, Lan-Dian& Cai, Yu-Dong. 2015. Identifying Novel Candidate Genes Related to Apoptosis from a Protein-Protein Interaction Network. Computational and Mathematical Methods in Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1057983
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Baoman…[et al.]. Identifying Novel Candidate Genes Related to Apoptosis from a Protein-Protein Interaction Network. Computational and Mathematical Methods in Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1057983
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Baoman& Yuan, Fei& Kong, Xiangyin& Hu, Lan-Dian& Cai, Yu-Dong. Identifying Novel Candidate Genes Related to Apoptosis from a Protein-Protein Interaction Network. Computational and Mathematical Methods in Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1057983
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057983
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر