Identifying Novel Candidate Genes Related to Apoptosis from a Protein-Protein Interaction Network
Joint Authors
Wang, Baoman
Hu, Lan-Dian
Cai, Yu-Dong
Yuan, Fei
Kong, Xiangyin
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Apoptosis is the process of programmed cell death (PCD) that occurs in multicellular organisms.
This process of normal cell death is required to maintain the balance of homeostasis.
In addition, some diseases, such as obesity, cancer, and neurodegenerative diseases, can be cured through apoptosis, which produces few side effects.
An effective comprehension of the mechanisms underlying apoptosis will be helpful to prevent and treat some diseases.
The identification of genes related to apoptosis is essential to uncover its underlying mechanisms.
In this study, a computational method was proposed to identify novel candidate genes related to apoptosis.
First, protein-protein interaction information was used to construct a weighted graph.
Second, a shortest path algorithm was applied to the graph to search for new candidate genes.
Finally, the obtained genes were filtered by a permutation test.
As a result, 26 genes were obtained, and we discuss their likelihood of being novel apoptosis-related genes by collecting evidence from published literature.
American Psychological Association (APA)
Wang, Baoman& Yuan, Fei& Kong, Xiangyin& Hu, Lan-Dian& Cai, Yu-Dong. 2015. Identifying Novel Candidate Genes Related to Apoptosis from a Protein-Protein Interaction Network. Computational and Mathematical Methods in Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1057983
Modern Language Association (MLA)
Wang, Baoman…[et al.]. Identifying Novel Candidate Genes Related to Apoptosis from a Protein-Protein Interaction Network. Computational and Mathematical Methods in Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1057983
American Medical Association (AMA)
Wang, Baoman& Yuan, Fei& Kong, Xiangyin& Hu, Lan-Dian& Cai, Yu-Dong. Identifying Novel Candidate Genes Related to Apoptosis from a Protein-Protein Interaction Network. Computational and Mathematical Methods in Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1057983
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057983