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Performance Enhancement of Pharmacokinetic Diffuse Fluorescence Tomography by Use of Adaptive Extended Kalman Filtering
المؤلفون المشاركون
Wang, Xin
Wu, Linhui
Yi, Xi
Zhang, Yanqi
Zhang, Limin
Zhao, Huijuan
Gao, Feng
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-19
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Due to both the physiological and morphological differences in the vascularization between healthy and diseased tissues, pharmacokinetic diffuse fluorescence tomography (DFT) can provide contrast-enhanced and comprehensive information for tumor diagnosis and staging.
In this regime, the extended Kalman filtering (EKF) based method shows numerous advantages including accurate modeling, online estimation of multiparameters, and universal applicability to any optical fluorophore.
Nevertheless the performance of the conventional EKF highly hinges on the exact and inaccessible prior knowledge about the initial values.
To address the above issues, an adaptive-EKF scheme is proposed based on a two-compartmental model for the enhancement, which utilizes a variable forgetting-factor to compensate the inaccuracy of the initial states and emphasize the effect of the current data.
It is demonstrated using two-dimensional simulative investigations on a circular domain that the proposed adaptive-EKF can obtain preferable estimation of the pharmacokinetic-rates to the conventional-EKF and the enhanced-EKF in terms of quantitativeness, noise robustness, and initialization independence.
Further three-dimensional numerical experiments on a digital mouse model validate the efficacy of the method as applied in realistic biological systems.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Xin& Wu, Linhui& Yi, Xi& Zhang, Yanqi& Zhao, Huijuan& Gao, Feng…[et al.]. 2015. Performance Enhancement of Pharmacokinetic Diffuse Fluorescence Tomography by Use of Adaptive Extended Kalman Filtering. Computational and Mathematical Methods in Medicine،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1057985
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Huijuan…[et al.]. Performance Enhancement of Pharmacokinetic Diffuse Fluorescence Tomography by Use of Adaptive Extended Kalman Filtering. Computational and Mathematical Methods in Medicine No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1057985
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Xin& Wu, Linhui& Yi, Xi& Zhang, Yanqi& Zhao, Huijuan& Gao, Feng…[et al.]. Performance Enhancement of Pharmacokinetic Diffuse Fluorescence Tomography by Use of Adaptive Extended Kalman Filtering. Computational and Mathematical Methods in Medicine. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1057985
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057985
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