![](/images/graphics-bg.png)
Performance Enhancement of Pharmacokinetic Diffuse Fluorescence Tomography by Use of Adaptive Extended Kalman Filtering
Joint Authors
Wang, Xin
Wu, Linhui
Yi, Xi
Zhang, Yanqi
Zhang, Limin
Zhao, Huijuan
Gao, Feng
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Due to both the physiological and morphological differences in the vascularization between healthy and diseased tissues, pharmacokinetic diffuse fluorescence tomography (DFT) can provide contrast-enhanced and comprehensive information for tumor diagnosis and staging.
In this regime, the extended Kalman filtering (EKF) based method shows numerous advantages including accurate modeling, online estimation of multiparameters, and universal applicability to any optical fluorophore.
Nevertheless the performance of the conventional EKF highly hinges on the exact and inaccessible prior knowledge about the initial values.
To address the above issues, an adaptive-EKF scheme is proposed based on a two-compartmental model for the enhancement, which utilizes a variable forgetting-factor to compensate the inaccuracy of the initial states and emphasize the effect of the current data.
It is demonstrated using two-dimensional simulative investigations on a circular domain that the proposed adaptive-EKF can obtain preferable estimation of the pharmacokinetic-rates to the conventional-EKF and the enhanced-EKF in terms of quantitativeness, noise robustness, and initialization independence.
Further three-dimensional numerical experiments on a digital mouse model validate the efficacy of the method as applied in realistic biological systems.
American Psychological Association (APA)
Wang, Xin& Wu, Linhui& Yi, Xi& Zhang, Yanqi& Zhao, Huijuan& Gao, Feng…[et al.]. 2015. Performance Enhancement of Pharmacokinetic Diffuse Fluorescence Tomography by Use of Adaptive Extended Kalman Filtering. Computational and Mathematical Methods in Medicine،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1057985
Modern Language Association (MLA)
Zhao, Huijuan…[et al.]. Performance Enhancement of Pharmacokinetic Diffuse Fluorescence Tomography by Use of Adaptive Extended Kalman Filtering. Computational and Mathematical Methods in Medicine No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1057985
American Medical Association (AMA)
Wang, Xin& Wu, Linhui& Yi, Xi& Zhang, Yanqi& Zhao, Huijuan& Gao, Feng…[et al.]. Performance Enhancement of Pharmacokinetic Diffuse Fluorescence Tomography by Use of Adaptive Extended Kalman Filtering. Computational and Mathematical Methods in Medicine. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1057985
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057985