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An Adverse Drug Reaction to Trimethoprim-Sulfamethoxazole Revealing Primary HIV: A Case Report and Literature Review
المؤلفون المشاركون
Meyer, Charles
Behm, Nicole
Brown, Emily
Copeland, Nathanial K.
Sklar, Marvin J.
المصدر
Case Reports in Infectious Diseases
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-21
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Adverse drug reactions (ADRs) to antibiotics complicate the management of any infection, particularly opportunistic infections in advanced HIV as some ADRs are potentiated by HIV.
Trimethoprim-sulfamethoxazole (TMP-SMX) causes ADRs in 40–80% of HIV infected individuals, compared to 3–5% in the general population.
The incidence and severity of ADRs among HIV infected individuals appear to increase as they progress from latent infection to AIDS.
We present a single case report of a 55-year-old African American male found to have an otherwise asymptomatic acute HIV infection who developed an ADR to TMP-SMX, despite having previously tolerating the medication.
The proposed mechanisms for the increased incidence of sulfa hypersensitivity reactions among HIV infected individuals focus on either (1) HIV-induced changes in the immune function driven by falling levels of CD4 cells or (2) other HIV-specific factors correlated with rising viral load.
To our knowledge this is the first reported case of new sulfa hypersensitivity in primary HIV and may provide clinical evidence to support the correlation between viral load and ADRs to TMP-SMX without a severely diminished CD4 count, though further research is necessary.
This case also demonstrates a rare and easily overlooked presentation of HIV that may aid in early diagnosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Meyer, Charles& Behm, Nicole& Brown, Emily& Copeland, Nathanial K.& Sklar, Marvin J.. 2015. An Adverse Drug Reaction to Trimethoprim-Sulfamethoxazole Revealing Primary HIV: A Case Report and Literature Review. Case Reports in Infectious Diseases،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058744
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Meyer, Charles…[et al.]. An Adverse Drug Reaction to Trimethoprim-Sulfamethoxazole Revealing Primary HIV: A Case Report and Literature Review. Case Reports in Infectious Diseases No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1058744
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Meyer, Charles& Behm, Nicole& Brown, Emily& Copeland, Nathanial K.& Sklar, Marvin J.. An Adverse Drug Reaction to Trimethoprim-Sulfamethoxazole Revealing Primary HIV: A Case Report and Literature Review. Case Reports in Infectious Diseases. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058744
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1058744
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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