A Case of Concurrent MPO-PR3-Negative ANCA-Associated Glomerulonephritis and Membranous Glomerulopathy

الملخص EN

We report a case in which antineutrophil cytoplasmic antibody- (ANCA-) associated glomerulonephritis and membranous glomerulopathy (MGN) were detected concurrently.

The patient showed rapidly progressive renal deterioration.

A renal biopsy showed crescentic glomerulonephritis, together with marked thickening and spike and bubbling formations in the glomerular basement membranes.

Indirect immunofluorescence examination of the patient’s neutrophils showed a perinuclear pattern.

Enzyme-linked immunosorbent assays revealed that the ANCA in this case did not target myeloperoxidase (MPO) or proteinase 3 (PR3) but bactericidal-/permeability-increasing protein, elastase, and lysosome.

The relationship between these two etiologically distinct entities, MPO-/PR3-negative ANCA-associated glomerulonephritis and MGN, remains unclear.