A Case of Concurrent MPO-PR3-Negative ANCA-Associated Glomerulonephritis and Membranous Glomerulopathy
Joint Authors
Nakada, Yasuyuki
Tsuboi, Nobuo
Takahashi, Yasuto
Yoshida, Hiraku
Hara, Yoriko
Okonogi, Hideo
Kawamura, Tetsuya
Arimura, Yoshihiro
Yokoo, Takashi
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-08
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We report a case in which antineutrophil cytoplasmic antibody- (ANCA-) associated glomerulonephritis and membranous glomerulopathy (MGN) were detected concurrently.
The patient showed rapidly progressive renal deterioration.
A renal biopsy showed crescentic glomerulonephritis, together with marked thickening and spike and bubbling formations in the glomerular basement membranes.
Indirect immunofluorescence examination of the patient’s neutrophils showed a perinuclear pattern.
Enzyme-linked immunosorbent assays revealed that the ANCA in this case did not target myeloperoxidase (MPO) or proteinase 3 (PR3) but bactericidal-/permeability-increasing protein, elastase, and lysosome.
The relationship between these two etiologically distinct entities, MPO-/PR3-negative ANCA-associated glomerulonephritis and MGN, remains unclear.
American Psychological Association (APA)
Nakada, Yasuyuki& Tsuboi, Nobuo& Takahashi, Yasuto& Yoshida, Hiraku& Hara, Yoriko& Okonogi, Hideo…[et al.]. 2015. A Case of Concurrent MPO-PR3-Negative ANCA-Associated Glomerulonephritis and Membranous Glomerulopathy. Case Reports in Nephrology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1058959
Modern Language Association (MLA)
Nakada, Yasuyuki…[et al.]. A Case of Concurrent MPO-PR3-Negative ANCA-Associated Glomerulonephritis and Membranous Glomerulopathy. Case Reports in Nephrology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1058959
American Medical Association (AMA)
Nakada, Yasuyuki& Tsuboi, Nobuo& Takahashi, Yasuto& Yoshida, Hiraku& Hara, Yoriko& Okonogi, Hideo…[et al.]. A Case of Concurrent MPO-PR3-Negative ANCA-Associated Glomerulonephritis and Membranous Glomerulopathy. Case Reports in Nephrology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1058959
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058959
