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Metastatic, Her-2 Amplified Lacrimal Gland Carcinoma with Response to Lapatinib Treatment
المؤلف
المصدر
Case Reports in Oncological Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-3، 3ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-02
دولة النشر
مصر
عدد الصفحات
3
التخصصات الرئيسية
الملخص EN
Carcinoma of the lacrimal gland is a rare malignancy, limiting opportunities to develop new therapeutic regimens through clinical trials.
There are no standard guidelines on optimal treatment of lacrimal gland carcinoma.
In addition, lacrimal gland carcinoma includes several different subtypes with distinct behavior and response to treatment, further complicating treatment.
Overexpression of the Her-2/neu protein, a potential target for new therapeutic agents, has previously been described in lacrimal gland carcinoma; however, there are no published reports regarding treatment of lacrimal gland cancer with Her-2 directed medications.
This case report describes treatment of a patient with metastatic lacrimal gland carcinoma with lapatinib, an oral agent with activity against Her-2/neu amplified malignancies.
In this case, Her-2 overexpression was confirmed by biopsy of a metastatic site.
PET imaging obtained 6 months after the initiation of lapatinib showed evidence of a partial response to treatment, although the patient later developed progressive neurologic complications related to her malignancy and ultimately died.
Lapatinib and other Her-2 targeted agents may represent an effective therapeutic option for this rare malignancy, in cases of metastatic disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dennie, Trevor. 2015. Metastatic, Her-2 Amplified Lacrimal Gland Carcinoma with Response to Lapatinib Treatment. Case Reports in Oncological Medicine،Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1059255
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dennie, Trevor. Metastatic, Her-2 Amplified Lacrimal Gland Carcinoma with Response to Lapatinib Treatment. Case Reports in Oncological Medicine No. 2015 (2015), pp.1-3.
https://search.emarefa.net/detail/BIM-1059255
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dennie, Trevor. Metastatic, Her-2 Amplified Lacrimal Gland Carcinoma with Response to Lapatinib Treatment. Case Reports in Oncological Medicine. 2015. Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1059255
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1059255
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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