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Metastatic, Her-2 Amplified Lacrimal Gland Carcinoma with Response to Lapatinib Treatment
Author
Source
Case Reports in Oncological Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-02
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Carcinoma of the lacrimal gland is a rare malignancy, limiting opportunities to develop new therapeutic regimens through clinical trials.
There are no standard guidelines on optimal treatment of lacrimal gland carcinoma.
In addition, lacrimal gland carcinoma includes several different subtypes with distinct behavior and response to treatment, further complicating treatment.
Overexpression of the Her-2/neu protein, a potential target for new therapeutic agents, has previously been described in lacrimal gland carcinoma; however, there are no published reports regarding treatment of lacrimal gland cancer with Her-2 directed medications.
This case report describes treatment of a patient with metastatic lacrimal gland carcinoma with lapatinib, an oral agent with activity against Her-2/neu amplified malignancies.
In this case, Her-2 overexpression was confirmed by biopsy of a metastatic site.
PET imaging obtained 6 months after the initiation of lapatinib showed evidence of a partial response to treatment, although the patient later developed progressive neurologic complications related to her malignancy and ultimately died.
Lapatinib and other Her-2 targeted agents may represent an effective therapeutic option for this rare malignancy, in cases of metastatic disease.
American Psychological Association (APA)
Dennie, Trevor. 2015. Metastatic, Her-2 Amplified Lacrimal Gland Carcinoma with Response to Lapatinib Treatment. Case Reports in Oncological Medicine،Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1059255
Modern Language Association (MLA)
Dennie, Trevor. Metastatic, Her-2 Amplified Lacrimal Gland Carcinoma with Response to Lapatinib Treatment. Case Reports in Oncological Medicine No. 2015 (2015), pp.1-3.
https://search.emarefa.net/detail/BIM-1059255
American Medical Association (AMA)
Dennie, Trevor. Metastatic, Her-2 Amplified Lacrimal Gland Carcinoma with Response to Lapatinib Treatment. Case Reports in Oncological Medicine. 2015. Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1059255
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059255