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Chemotherapy in the Setting of Severe Liver Dysfunction in Patients with Metastatic Colorectal Cancer
المؤلفون المشاركون
Kasi, Pashtoon Murtaza
Hubbard, Joleen
Thanarajasingam, Gita
Finnes, Heidi D.
Villasboas Bisneto, Jose C.
Grothey, Axel
المصدر
Case Reports in Oncological Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-21
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The liver is the dominant site of metastases for patients with metastatic colorectal cancer (mCRC).
Depending on the timing of diagnosis and the biology of the disease, it is not uncommon for these patients to present with visceral crisis in the form of severe liver dysfunction.
Treatment of these individuals is, however, difficult and challenging.
The decision to consider chemotherapy in these dire circumstances entails consideration of numerous factors.
If we were to focus on just the metabolism of the different drugs and biologic agents available to treat mCRC, both 5-fluorouracil and oxaliplatin alone or in combination with a monoclonal antibody are reasonable choices.
Specifically, FOLFOX is a feasible and safe option in patients with mCRC with severe liver dysfunction.
Choice of the biologic agent to add to the doublet chemotherapy could be individualized based on the RAS status and the clinical scenario.
Based on the divergent experience of treating 2 cases and other prior reports, a summary of recommendations with a model in the form of a “therapeutic triad” is presented.
The paper highlights the therapeutic challenges in patients with mCRC and severe liver dysfunction.
The choice of chemotherapeutic agents and reports of other cases/series is also presented.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kasi, Pashtoon Murtaza& Thanarajasingam, Gita& Finnes, Heidi D.& Villasboas Bisneto, Jose C.& Hubbard, Joleen& Grothey, Axel. 2015. Chemotherapy in the Setting of Severe Liver Dysfunction in Patients with Metastatic Colorectal Cancer. Case Reports in Oncological Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1059275
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kasi, Pashtoon Murtaza…[et al.]. Chemotherapy in the Setting of Severe Liver Dysfunction in Patients with Metastatic Colorectal Cancer. Case Reports in Oncological Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1059275
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kasi, Pashtoon Murtaza& Thanarajasingam, Gita& Finnes, Heidi D.& Villasboas Bisneto, Jose C.& Hubbard, Joleen& Grothey, Axel. Chemotherapy in the Setting of Severe Liver Dysfunction in Patients with Metastatic Colorectal Cancer. Case Reports in Oncological Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1059275
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1059275
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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