Chemotherapy in the Setting of Severe Liver Dysfunction in Patients with Metastatic Colorectal Cancer
Joint Authors
Kasi, Pashtoon Murtaza
Hubbard, Joleen
Thanarajasingam, Gita
Finnes, Heidi D.
Villasboas Bisneto, Jose C.
Grothey, Axel
Source
Case Reports in Oncological Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The liver is the dominant site of metastases for patients with metastatic colorectal cancer (mCRC).
Depending on the timing of diagnosis and the biology of the disease, it is not uncommon for these patients to present with visceral crisis in the form of severe liver dysfunction.
Treatment of these individuals is, however, difficult and challenging.
The decision to consider chemotherapy in these dire circumstances entails consideration of numerous factors.
If we were to focus on just the metabolism of the different drugs and biologic agents available to treat mCRC, both 5-fluorouracil and oxaliplatin alone or in combination with a monoclonal antibody are reasonable choices.
Specifically, FOLFOX is a feasible and safe option in patients with mCRC with severe liver dysfunction.
Choice of the biologic agent to add to the doublet chemotherapy could be individualized based on the RAS status and the clinical scenario.
Based on the divergent experience of treating 2 cases and other prior reports, a summary of recommendations with a model in the form of a “therapeutic triad” is presented.
The paper highlights the therapeutic challenges in patients with mCRC and severe liver dysfunction.
The choice of chemotherapeutic agents and reports of other cases/series is also presented.
American Psychological Association (APA)
Kasi, Pashtoon Murtaza& Thanarajasingam, Gita& Finnes, Heidi D.& Villasboas Bisneto, Jose C.& Hubbard, Joleen& Grothey, Axel. 2015. Chemotherapy in the Setting of Severe Liver Dysfunction in Patients with Metastatic Colorectal Cancer. Case Reports in Oncological Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1059275
Modern Language Association (MLA)
Kasi, Pashtoon Murtaza…[et al.]. Chemotherapy in the Setting of Severe Liver Dysfunction in Patients with Metastatic Colorectal Cancer. Case Reports in Oncological Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1059275
American Medical Association (AMA)
Kasi, Pashtoon Murtaza& Thanarajasingam, Gita& Finnes, Heidi D.& Villasboas Bisneto, Jose C.& Hubbard, Joleen& Grothey, Axel. Chemotherapy in the Setting of Severe Liver Dysfunction in Patients with Metastatic Colorectal Cancer. Case Reports in Oncological Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1059275
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059275