Progression of an Invasive ACTH Pituitary Macroadenoma with Cushing’s Disease to Pituitary Carcinoma
المؤلفون المشاركون
Borba, Clarissa Groberio
Batista, Rafael Loch
Musolino, Nina Rosa de Castro
Machado, Vanielle Carvalho
Alcantara, Ana Elisa Evangelista
Silva, Gilberto Ochman da
Sperling Cescato, Valter Angelo
Cunha Neto, Malebranche Berardo Carneiro da
المصدر
Case Reports in Oncological Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-20
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Pituitary carcinomas are very rare tumors that in most cases produce prolactin and adrenocorticotropic hormone (ACTH).
It is a challenge to diagnosis of a pituitary carcinoma before disclosed symptomatic metastasis.
We report the case of a female patient with Cushing’s disease who underwent three transsphenoidal surgeries, with pathological findings of common ACTH pituitary adenoma including Ki-67 expression <3%.
She achieved hypocortisolism after the 3rd surgery although ACTH levels remained slightly elevated.
The patient returned some time later with fast worsening of hypercortisolism.
Magnetic resonance imaging showed clivus invasion, which led to a fourth surgery and radiation.
This time, immunohistochemistry revealed strong Ki-67 (10% to 15%) and p53 expression.
Liver and lumbar spine metastases were found on workup.
The patient died after few months due to lung infection.
Pituitary carcinomas are rare, and the transformation of an ACTH-secreting pituitary adenoma into a carcinoma is exceptional.
The difficulty of defining markers for the diagnosis of carcinoma, before metastasis diagnosis, in order to change the management of the disease, is a challenge.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Borba, Clarissa Groberio& Batista, Rafael Loch& Musolino, Nina Rosa de Castro& Machado, Vanielle Carvalho& Alcantara, Ana Elisa Evangelista& Silva, Gilberto Ochman da…[et al.]. 2015. Progression of an Invasive ACTH Pituitary Macroadenoma with Cushing’s Disease to Pituitary Carcinoma. Case Reports in Oncological Medicine،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1059312
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Borba, Clarissa Groberio…[et al.]. Progression of an Invasive ACTH Pituitary Macroadenoma with Cushing’s Disease to Pituitary Carcinoma. Case Reports in Oncological Medicine No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1059312
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Borba, Clarissa Groberio& Batista, Rafael Loch& Musolino, Nina Rosa de Castro& Machado, Vanielle Carvalho& Alcantara, Ana Elisa Evangelista& Silva, Gilberto Ochman da…[et al.]. Progression of an Invasive ACTH Pituitary Macroadenoma with Cushing’s Disease to Pituitary Carcinoma. Case Reports in Oncological Medicine. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1059312
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1059312
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر