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Progression of an Invasive ACTH Pituitary Macroadenoma with Cushing’s Disease to Pituitary Carcinoma
Joint Authors
Borba, Clarissa Groberio
Batista, Rafael Loch
Musolino, Nina Rosa de Castro
Machado, Vanielle Carvalho
Alcantara, Ana Elisa Evangelista
Silva, Gilberto Ochman da
Sperling Cescato, Valter Angelo
Cunha Neto, Malebranche Berardo Carneiro da
Source
Case Reports in Oncological Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-20
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Pituitary carcinomas are very rare tumors that in most cases produce prolactin and adrenocorticotropic hormone (ACTH).
It is a challenge to diagnosis of a pituitary carcinoma before disclosed symptomatic metastasis.
We report the case of a female patient with Cushing’s disease who underwent three transsphenoidal surgeries, with pathological findings of common ACTH pituitary adenoma including Ki-67 expression <3%.
She achieved hypocortisolism after the 3rd surgery although ACTH levels remained slightly elevated.
The patient returned some time later with fast worsening of hypercortisolism.
Magnetic resonance imaging showed clivus invasion, which led to a fourth surgery and radiation.
This time, immunohistochemistry revealed strong Ki-67 (10% to 15%) and p53 expression.
Liver and lumbar spine metastases were found on workup.
The patient died after few months due to lung infection.
Pituitary carcinomas are rare, and the transformation of an ACTH-secreting pituitary adenoma into a carcinoma is exceptional.
The difficulty of defining markers for the diagnosis of carcinoma, before metastasis diagnosis, in order to change the management of the disease, is a challenge.
American Psychological Association (APA)
Borba, Clarissa Groberio& Batista, Rafael Loch& Musolino, Nina Rosa de Castro& Machado, Vanielle Carvalho& Alcantara, Ana Elisa Evangelista& Silva, Gilberto Ochman da…[et al.]. 2015. Progression of an Invasive ACTH Pituitary Macroadenoma with Cushing’s Disease to Pituitary Carcinoma. Case Reports in Oncological Medicine،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1059312
Modern Language Association (MLA)
Borba, Clarissa Groberio…[et al.]. Progression of an Invasive ACTH Pituitary Macroadenoma with Cushing’s Disease to Pituitary Carcinoma. Case Reports in Oncological Medicine No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1059312
American Medical Association (AMA)
Borba, Clarissa Groberio& Batista, Rafael Loch& Musolino, Nina Rosa de Castro& Machado, Vanielle Carvalho& Alcantara, Ana Elisa Evangelista& Silva, Gilberto Ochman da…[et al.]. Progression of an Invasive ACTH Pituitary Macroadenoma with Cushing’s Disease to Pituitary Carcinoma. Case Reports in Oncological Medicine. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1059312
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059312