A Rare Case of Paclitaxel andor Trastuzumab Induced Acute Hepatic Necrosis
المؤلفون المشاركون
Mandaliya, Hiren
Baghi, Pinky
Prawira, Amy
George, Mathew K.
المصدر
Case Reports in Oncological Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-2، 2ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-29
دولة النشر
مصر
عدد الصفحات
2
التخصصات الرئيسية
الملخص EN
Paclitaxel induced mild derangement of liver functions including bilirubin, alkaline phosphatase, and AST has been infrequently noticed in clinical trials.
Contrary to Paclitaxel, hepatocellular injury, hepatitis, and liver tenderness are common laboratory and clinical findings with Trastuzumab.
However, hepatic failure/necrosis secondary to Paclitaxel or Trastuzumab has never been reported in literature.
A 62-year-old lady, previously healthy, was treated with adjuvant therapy for left breast stage II, high grade invasive ductal carcinoma which was node negative, oestrogen receptor negative, progesterone receptor positive, and HER2 receptor positive.
After modified radical mastectomy and axillary clearance, she finished four cycles of Doxorubicin/Cyclophosphamide chemotherapy and then commenced on Paclitaxel/Trastuzumab combination chemotherapy.
Within twelve hours of first dose of Paclitaxel/Trastuzumab therapy, patient required hospital admission for acute onset respiratory failure.
Patient died within 36 hours of therapy and autopsy was suggestive of acute hepatic necrosis without any other significant findings.
Detailed investigations were not carried out as event was quick with rapid deterioration.
There was no history of prior liver pathology/injury and preliminary investigations for major organ involvement were unremarkable.
As per our knowledge, Paclitaxel and/or Trastuzumab induced acute hepatic necrosis has never been reported in literature before, hence difficult to predict.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mandaliya, Hiren& Baghi, Pinky& Prawira, Amy& George, Mathew K.. 2015. A Rare Case of Paclitaxel andor Trastuzumab Induced Acute Hepatic Necrosis. Case Reports in Oncological Medicine،Vol. 2015, no. 2015, pp.1-2.
https://search.emarefa.net/detail/BIM-1059315
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mandaliya, Hiren…[et al.]. A Rare Case of Paclitaxel andor Trastuzumab Induced Acute Hepatic Necrosis. Case Reports in Oncological Medicine No. 2015 (2015), pp.1-2.
https://search.emarefa.net/detail/BIM-1059315
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mandaliya, Hiren& Baghi, Pinky& Prawira, Amy& George, Mathew K.. A Rare Case of Paclitaxel andor Trastuzumab Induced Acute Hepatic Necrosis. Case Reports in Oncological Medicine. 2015. Vol. 2015, no. 2015, pp.1-2.
https://search.emarefa.net/detail/BIM-1059315
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1059315
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر