A Rare Case of Paclitaxel andor Trastuzumab Induced Acute Hepatic Necrosis
Joint Authors
Mandaliya, Hiren
Baghi, Pinky
Prawira, Amy
George, Mathew K.
Source
Case Reports in Oncological Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-2, 2 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-29
Country of Publication
Egypt
No. of Pages
2
Main Subjects
Abstract EN
Paclitaxel induced mild derangement of liver functions including bilirubin, alkaline phosphatase, and AST has been infrequently noticed in clinical trials.
Contrary to Paclitaxel, hepatocellular injury, hepatitis, and liver tenderness are common laboratory and clinical findings with Trastuzumab.
However, hepatic failure/necrosis secondary to Paclitaxel or Trastuzumab has never been reported in literature.
A 62-year-old lady, previously healthy, was treated with adjuvant therapy for left breast stage II, high grade invasive ductal carcinoma which was node negative, oestrogen receptor negative, progesterone receptor positive, and HER2 receptor positive.
After modified radical mastectomy and axillary clearance, she finished four cycles of Doxorubicin/Cyclophosphamide chemotherapy and then commenced on Paclitaxel/Trastuzumab combination chemotherapy.
Within twelve hours of first dose of Paclitaxel/Trastuzumab therapy, patient required hospital admission for acute onset respiratory failure.
Patient died within 36 hours of therapy and autopsy was suggestive of acute hepatic necrosis without any other significant findings.
Detailed investigations were not carried out as event was quick with rapid deterioration.
There was no history of prior liver pathology/injury and preliminary investigations for major organ involvement were unremarkable.
As per our knowledge, Paclitaxel and/or Trastuzumab induced acute hepatic necrosis has never been reported in literature before, hence difficult to predict.
American Psychological Association (APA)
Mandaliya, Hiren& Baghi, Pinky& Prawira, Amy& George, Mathew K.. 2015. A Rare Case of Paclitaxel andor Trastuzumab Induced Acute Hepatic Necrosis. Case Reports in Oncological Medicine،Vol. 2015, no. 2015, pp.1-2.
https://search.emarefa.net/detail/BIM-1059315
Modern Language Association (MLA)
Mandaliya, Hiren…[et al.]. A Rare Case of Paclitaxel andor Trastuzumab Induced Acute Hepatic Necrosis. Case Reports in Oncological Medicine No. 2015 (2015), pp.1-2.
https://search.emarefa.net/detail/BIM-1059315
American Medical Association (AMA)
Mandaliya, Hiren& Baghi, Pinky& Prawira, Amy& George, Mathew K.. A Rare Case of Paclitaxel andor Trastuzumab Induced Acute Hepatic Necrosis. Case Reports in Oncological Medicine. 2015. Vol. 2015, no. 2015, pp.1-2.
https://search.emarefa.net/detail/BIM-1059315
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059315