Clinicopathological and Targeted Exome Gene Features of a Patient with Metastatic Acinic Cell Carcinoma of the Parotid Gland Harboring an ARID2 Nonsense Mutation and CDKN2AB Deletion
المؤلفون المشاركون
Palma Diaz, Miguel Fernando
Warner, Wayne A.
Wong, Deborah J.
Shibuya, Terry Y.
Momand, Jamil
المصدر
Case Reports in Oncological Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-08
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
We describe the presentation, treatment, clinical outcome, and targeted genome analysis of a metastatic salivary acinic cell carcinoma (AciCC).
A 71-year-old male presented with a 3 cm right tail of a parotid lesion, first detected as a nodule by the patient seven months earlier.
He had a right total parotidectomy with cranial nerve VII resection, right facial nerve resection and grafting, resection of the right conchal cartilage, and right modified radical neck dissection.
The primary tumor revealed AciCC with two distinct areas: a well-differentiated component with glandular architecture and a dedifferentiated component with infiltrative growth pattern associated with prominent stromal response, necrosis, perineural invasion, and cellular pleomorphism.
Tumor staging was pT4 N0 MX.
Immunohistochemistry staining showed pankeratin (+), CD56 (−), and a Ki67 proliferation index of 15%.
Upon microscopic inspection, 49 local lymph nodes resected during parotidectomy were negative for cancer cells.
Targeted sequencing of the primary tumor revealed deletions of CDKN2A and CDKN2B, a nonsense mutation in ARID2, and single missense mutations of unknown significance in nine other genes.
Despite postoperative localized radiation treatment, follow-up whole body PET/CT scan showed lung, soft tissue, bone, and liver metastases.
The patient expired 9 months after resection of the primary tumor.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Warner, Wayne A.& Wong, Deborah J.& Palma Diaz, Miguel Fernando& Shibuya, Terry Y.& Momand, Jamil. 2015. Clinicopathological and Targeted Exome Gene Features of a Patient with Metastatic Acinic Cell Carcinoma of the Parotid Gland Harboring an ARID2 Nonsense Mutation and CDKN2AB Deletion. Case Reports in Oncological Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1059325
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Warner, Wayne A.…[et al.]. Clinicopathological and Targeted Exome Gene Features of a Patient with Metastatic Acinic Cell Carcinoma of the Parotid Gland Harboring an ARID2 Nonsense Mutation and CDKN2AB Deletion. Case Reports in Oncological Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1059325
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Warner, Wayne A.& Wong, Deborah J.& Palma Diaz, Miguel Fernando& Shibuya, Terry Y.& Momand, Jamil. Clinicopathological and Targeted Exome Gene Features of a Patient with Metastatic Acinic Cell Carcinoma of the Parotid Gland Harboring an ARID2 Nonsense Mutation and CDKN2AB Deletion. Case Reports in Oncological Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1059325
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1059325
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر