Clinicopathological and Targeted Exome Gene Features of a Patient with Metastatic Acinic Cell Carcinoma of the Parotid Gland Harboring an ARID2 Nonsense Mutation and CDKN2AB Deletion

Joint Authors

Palma Diaz, Miguel Fernando
Warner, Wayne A.
Wong, Deborah J.
Shibuya, Terry Y.
Momand, Jamil

Source

Case Reports in Oncological Medicine

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-11-08

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Abstract EN

We describe the presentation, treatment, clinical outcome, and targeted genome analysis of a metastatic salivary acinic cell carcinoma (AciCC).

A 71-year-old male presented with a 3 cm right tail of a parotid lesion, first detected as a nodule by the patient seven months earlier.

He had a right total parotidectomy with cranial nerve VII resection, right facial nerve resection and grafting, resection of the right conchal cartilage, and right modified radical neck dissection.

The primary tumor revealed AciCC with two distinct areas: a well-differentiated component with glandular architecture and a dedifferentiated component with infiltrative growth pattern associated with prominent stromal response, necrosis, perineural invasion, and cellular pleomorphism.

Tumor staging was pT4 N0 MX.

Immunohistochemistry staining showed pankeratin (+), CD56 (−), and a Ki67 proliferation index of 15%.

Upon microscopic inspection, 49 local lymph nodes resected during parotidectomy were negative for cancer cells.

Targeted sequencing of the primary tumor revealed deletions of CDKN2A and CDKN2B, a nonsense mutation in ARID2, and single missense mutations of unknown significance in nine other genes.

Despite postoperative localized radiation treatment, follow-up whole body PET/CT scan showed lung, soft tissue, bone, and liver metastases.

The patient expired 9 months after resection of the primary tumor.

American Psychological Association (APA)

Warner, Wayne A.& Wong, Deborah J.& Palma Diaz, Miguel Fernando& Shibuya, Terry Y.& Momand, Jamil. 2015. Clinicopathological and Targeted Exome Gene Features of a Patient with Metastatic Acinic Cell Carcinoma of the Parotid Gland Harboring an ARID2 Nonsense Mutation and CDKN2AB Deletion. Case Reports in Oncological Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1059325

Modern Language Association (MLA)

Warner, Wayne A.…[et al.]. Clinicopathological and Targeted Exome Gene Features of a Patient with Metastatic Acinic Cell Carcinoma of the Parotid Gland Harboring an ARID2 Nonsense Mutation and CDKN2AB Deletion. Case Reports in Oncological Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1059325

American Medical Association (AMA)

Warner, Wayne A.& Wong, Deborah J.& Palma Diaz, Miguel Fernando& Shibuya, Terry Y.& Momand, Jamil. Clinicopathological and Targeted Exome Gene Features of a Patient with Metastatic Acinic Cell Carcinoma of the Parotid Gland Harboring an ARID2 Nonsense Mutation and CDKN2AB Deletion. Case Reports in Oncological Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1059325

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1059325