Clinicopathological and Targeted Exome Gene Features of a Patient with Metastatic Acinic Cell Carcinoma of the Parotid Gland Harboring an ARID2 Nonsense Mutation and CDKN2AB Deletion
Joint Authors
Palma Diaz, Miguel Fernando
Warner, Wayne A.
Wong, Deborah J.
Shibuya, Terry Y.
Momand, Jamil
Source
Case Reports in Oncological Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We describe the presentation, treatment, clinical outcome, and targeted genome analysis of a metastatic salivary acinic cell carcinoma (AciCC).
A 71-year-old male presented with a 3 cm right tail of a parotid lesion, first detected as a nodule by the patient seven months earlier.
He had a right total parotidectomy with cranial nerve VII resection, right facial nerve resection and grafting, resection of the right conchal cartilage, and right modified radical neck dissection.
The primary tumor revealed AciCC with two distinct areas: a well-differentiated component with glandular architecture and a dedifferentiated component with infiltrative growth pattern associated with prominent stromal response, necrosis, perineural invasion, and cellular pleomorphism.
Tumor staging was pT4 N0 MX.
Immunohistochemistry staining showed pankeratin (+), CD56 (−), and a Ki67 proliferation index of 15%.
Upon microscopic inspection, 49 local lymph nodes resected during parotidectomy were negative for cancer cells.
Targeted sequencing of the primary tumor revealed deletions of CDKN2A and CDKN2B, a nonsense mutation in ARID2, and single missense mutations of unknown significance in nine other genes.
Despite postoperative localized radiation treatment, follow-up whole body PET/CT scan showed lung, soft tissue, bone, and liver metastases.
The patient expired 9 months after resection of the primary tumor.
American Psychological Association (APA)
Warner, Wayne A.& Wong, Deborah J.& Palma Diaz, Miguel Fernando& Shibuya, Terry Y.& Momand, Jamil. 2015. Clinicopathological and Targeted Exome Gene Features of a Patient with Metastatic Acinic Cell Carcinoma of the Parotid Gland Harboring an ARID2 Nonsense Mutation and CDKN2AB Deletion. Case Reports in Oncological Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1059325
Modern Language Association (MLA)
Warner, Wayne A.…[et al.]. Clinicopathological and Targeted Exome Gene Features of a Patient with Metastatic Acinic Cell Carcinoma of the Parotid Gland Harboring an ARID2 Nonsense Mutation and CDKN2AB Deletion. Case Reports in Oncological Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1059325
American Medical Association (AMA)
Warner, Wayne A.& Wong, Deborah J.& Palma Diaz, Miguel Fernando& Shibuya, Terry Y.& Momand, Jamil. Clinicopathological and Targeted Exome Gene Features of a Patient with Metastatic Acinic Cell Carcinoma of the Parotid Gland Harboring an ARID2 Nonsense Mutation and CDKN2AB Deletion. Case Reports in Oncological Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1059325
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059325