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Articular Cartilage Repair Using Marrow Stimulation Augmented with a Viable Chondral Allograft: 9-Month Postoperative Histological Evaluation
المؤلفون المشاركون
Hoffman, James K.
Protzman, Nicole M.
Geraghty, Sandra
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-01
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Marrow stimulation is frequently employed to treat focal chondral defects of the knee.
However, marrow stimulation typically results in fibrocartilage repair tissue rather than healthy hyaline cartilage, which, over time, predisposes the repair to failure.
Recently, a cryopreserved viable chondral allograft was developed to augment marrow stimulation.
The chondral allograft is comprised of native viable chondrocytes, chondrogenic growth factors, and extracellular matrix proteins within the superficial, transitional, and radial zones of hyaline cartilage.
Therefore, host mesenchymal stem cells that infiltrate the graft from the underlying bone marrow following marrow stimulation are provided with the optimal microenvironment to undergo chondrogenesis.
The present report describes treatment of a trochlear defect with marrow stimulation augmented with this novel chondral allograft, along with nine month postoperative histological results.
At nine months, the patient demonstrated complete resolution of pain and improvement in function, and the repair tissue consisted of 85% hyaline cartilage.
For comparison, a biopsy obtained from a patient 8.2 months after treatment with marrow stimulation alone contained only 5% hyaline cartilage.
These outcomes suggest that augmenting marrow stimulation with the viable chondral allograft can eliminate pain and improve outcomes, compared with marrow stimulation alone.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hoffman, James K.& Geraghty, Sandra& Protzman, Nicole M.. 2015. Articular Cartilage Repair Using Marrow Stimulation Augmented with a Viable Chondral Allograft: 9-Month Postoperative Histological Evaluation. Case Reports in Orthopedics،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1059511
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hoffman, James K.…[et al.]. Articular Cartilage Repair Using Marrow Stimulation Augmented with a Viable Chondral Allograft: 9-Month Postoperative Histological Evaluation. Case Reports in Orthopedics No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1059511
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hoffman, James K.& Geraghty, Sandra& Protzman, Nicole M.. Articular Cartilage Repair Using Marrow Stimulation Augmented with a Viable Chondral Allograft: 9-Month Postoperative Histological Evaluation. Case Reports in Orthopedics. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1059511
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1059511
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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