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Articular Cartilage Repair Using Marrow Stimulation Augmented with a Viable Chondral Allograft: 9-Month Postoperative Histological Evaluation
Joint Authors
Hoffman, James K.
Protzman, Nicole M.
Geraghty, Sandra
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Marrow stimulation is frequently employed to treat focal chondral defects of the knee.
However, marrow stimulation typically results in fibrocartilage repair tissue rather than healthy hyaline cartilage, which, over time, predisposes the repair to failure.
Recently, a cryopreserved viable chondral allograft was developed to augment marrow stimulation.
The chondral allograft is comprised of native viable chondrocytes, chondrogenic growth factors, and extracellular matrix proteins within the superficial, transitional, and radial zones of hyaline cartilage.
Therefore, host mesenchymal stem cells that infiltrate the graft from the underlying bone marrow following marrow stimulation are provided with the optimal microenvironment to undergo chondrogenesis.
The present report describes treatment of a trochlear defect with marrow stimulation augmented with this novel chondral allograft, along with nine month postoperative histological results.
At nine months, the patient demonstrated complete resolution of pain and improvement in function, and the repair tissue consisted of 85% hyaline cartilage.
For comparison, a biopsy obtained from a patient 8.2 months after treatment with marrow stimulation alone contained only 5% hyaline cartilage.
These outcomes suggest that augmenting marrow stimulation with the viable chondral allograft can eliminate pain and improve outcomes, compared with marrow stimulation alone.
American Psychological Association (APA)
Hoffman, James K.& Geraghty, Sandra& Protzman, Nicole M.. 2015. Articular Cartilage Repair Using Marrow Stimulation Augmented with a Viable Chondral Allograft: 9-Month Postoperative Histological Evaluation. Case Reports in Orthopedics،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1059511
Modern Language Association (MLA)
Hoffman, James K.…[et al.]. Articular Cartilage Repair Using Marrow Stimulation Augmented with a Viable Chondral Allograft: 9-Month Postoperative Histological Evaluation. Case Reports in Orthopedics No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1059511
American Medical Association (AMA)
Hoffman, James K.& Geraghty, Sandra& Protzman, Nicole M.. Articular Cartilage Repair Using Marrow Stimulation Augmented with a Viable Chondral Allograft: 9-Month Postoperative Histological Evaluation. Case Reports in Orthopedics. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1059511
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059511