Immunophenotype Heterogeneity in Nasal Glomangiopericytoma

الملخص EN

Nasal glomangiopericytoma is rare.

The immunophenotype is heterogeneous, more frequently smooth-muscle-actin and CD34-positive.

We report expression patterns for several vascular-related proteins such as CD99, CD146, Bcl2, and WT1 as well as for treatment-related proteins such as mTOR and EGFR in a nasal glomangiopericytoma.

The patient (woman, 86 years) presented with a left nasal tumefaction.

The resected specimen (1.5-cm) showed a glomangiopericytoma.

Tumor cells expressed smooth-muscle-actin, CD31, CD34, and progesterone receptor.

They also expressed the vascular-cell-related proteins Bcl2, CD99, CD146, and WT1, as well as mTOR and EGFR.

Nasal glomangiopericytomas show immunohistochemical heterogeneity for vascular-related markers, suggesting a possible extensive pericytic differentiation.

The expression of potential targets for drug treatments such as mTOR and EGFR may impact on the clinical follow-up of these tumors occurring at advanced ages, which may require complex surgery.