Immunophenotype Heterogeneity in Nasal Glomangiopericytoma
Joint Authors
Handra-Luca, Adriana
Abd Elmageed, Zakaria Y.
Magkou, Christina
Lae, Marick
Source
Case Reports in Otolaryngology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-17
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Nasal glomangiopericytoma is rare.
The immunophenotype is heterogeneous, more frequently smooth-muscle-actin and CD34-positive.
We report expression patterns for several vascular-related proteins such as CD99, CD146, Bcl2, and WT1 as well as for treatment-related proteins such as mTOR and EGFR in a nasal glomangiopericytoma.
The patient (woman, 86 years) presented with a left nasal tumefaction.
The resected specimen (1.5-cm) showed a glomangiopericytoma.
Tumor cells expressed smooth-muscle-actin, CD31, CD34, and progesterone receptor.
They also expressed the vascular-cell-related proteins Bcl2, CD99, CD146, and WT1, as well as mTOR and EGFR.
Nasal glomangiopericytomas show immunohistochemical heterogeneity for vascular-related markers, suggesting a possible extensive pericytic differentiation.
The expression of potential targets for drug treatments such as mTOR and EGFR may impact on the clinical follow-up of these tumors occurring at advanced ages, which may require complex surgery.
American Psychological Association (APA)
Handra-Luca, Adriana& Abd Elmageed, Zakaria Y.& Magkou, Christina& Lae, Marick. 2015. Immunophenotype Heterogeneity in Nasal Glomangiopericytoma. Case Reports in Otolaryngology،Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1059610
Modern Language Association (MLA)
Handra-Luca, Adriana…[et al.]. Immunophenotype Heterogeneity in Nasal Glomangiopericytoma. Case Reports in Otolaryngology No. 2015 (2015), pp.1-3.
https://search.emarefa.net/detail/BIM-1059610
American Medical Association (AMA)
Handra-Luca, Adriana& Abd Elmageed, Zakaria Y.& Magkou, Christina& Lae, Marick. Immunophenotype Heterogeneity in Nasal Glomangiopericytoma. Case Reports in Otolaryngology. 2015. Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1059610
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059610