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Liver Transplant in a Patient under Methylphenidate Therapy: A Case Report and Review of the Literature
المؤلفون المشاركون
Tong, Hoi Y.
Díaz, Carmen
Collantes, Elena
Medrano, Nicolás
Borobia, Alberto M.
Jara, Paloma
Ramírez, Elena
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-22
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Methylphenidate (MPH) is widely used in treating children with attention-deficit-hyperactivity disorder.
Hepatotoxicity is a rare phenomenon; only few cases are described with no liver failure.
Case.
We report on the case of a 12-year-old boy who received MPH for attention-deficit-hyperactivity disorder.
Two months later the patient presented with signs and symptoms of hepatitis and MPH was discontinued, showing progressive worsening and developing liver failure and a liver transplantation was required.
Other causes of liver failure were ruled out and the liver biopsy was suggestive of drug toxicity.
Discussion.
One rare adverse reaction of MPH is hepatotoxicity.
The review of the literature shows few cases of liver injury attributed to MPH; all of them recovered after withdrawing the treatment.
The probable mechanism of liver injury was MPH direct toxicity to hepatocytes.
In order to establish the diagnosis of MPH-induced liver injury, we used CIOMS/RUCAM scale that led to an assessment of “possible” relationship.
This report provides the first published case of acute MPH-induced liver failure with successful hepatic transplantation.
Conclusions.
It is important to know that hepatotoxicity can occur in patients with MPH treatment and monitoring the liver’s function is highly recommended.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tong, Hoi Y.& Díaz, Carmen& Collantes, Elena& Medrano, Nicolás& Borobia, Alberto M.& Jara, Paloma…[et al.]. 2015. Liver Transplant in a Patient under Methylphenidate Therapy: A Case Report and Review of the Literature. Case Reports in Pediatrics،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059771
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tong, Hoi Y.…[et al.]. Liver Transplant in a Patient under Methylphenidate Therapy: A Case Report and Review of the Literature. Case Reports in Pediatrics No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1059771
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tong, Hoi Y.& Díaz, Carmen& Collantes, Elena& Medrano, Nicolás& Borobia, Alberto M.& Jara, Paloma…[et al.]. Liver Transplant in a Patient under Methylphenidate Therapy: A Case Report and Review of the Literature. Case Reports in Pediatrics. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059771
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1059771
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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