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Liver Transplant in a Patient under Methylphenidate Therapy: A Case Report and Review of the Literature
Joint Authors
Tong, Hoi Y.
Díaz, Carmen
Collantes, Elena
Medrano, Nicolás
Borobia, Alberto M.
Jara, Paloma
Ramírez, Elena
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-22
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Methylphenidate (MPH) is widely used in treating children with attention-deficit-hyperactivity disorder.
Hepatotoxicity is a rare phenomenon; only few cases are described with no liver failure.
Case.
We report on the case of a 12-year-old boy who received MPH for attention-deficit-hyperactivity disorder.
Two months later the patient presented with signs and symptoms of hepatitis and MPH was discontinued, showing progressive worsening and developing liver failure and a liver transplantation was required.
Other causes of liver failure were ruled out and the liver biopsy was suggestive of drug toxicity.
Discussion.
One rare adverse reaction of MPH is hepatotoxicity.
The review of the literature shows few cases of liver injury attributed to MPH; all of them recovered after withdrawing the treatment.
The probable mechanism of liver injury was MPH direct toxicity to hepatocytes.
In order to establish the diagnosis of MPH-induced liver injury, we used CIOMS/RUCAM scale that led to an assessment of “possible” relationship.
This report provides the first published case of acute MPH-induced liver failure with successful hepatic transplantation.
Conclusions.
It is important to know that hepatotoxicity can occur in patients with MPH treatment and monitoring the liver’s function is highly recommended.
American Psychological Association (APA)
Tong, Hoi Y.& Díaz, Carmen& Collantes, Elena& Medrano, Nicolás& Borobia, Alberto M.& Jara, Paloma…[et al.]. 2015. Liver Transplant in a Patient under Methylphenidate Therapy: A Case Report and Review of the Literature. Case Reports in Pediatrics،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059771
Modern Language Association (MLA)
Tong, Hoi Y.…[et al.]. Liver Transplant in a Patient under Methylphenidate Therapy: A Case Report and Review of the Literature. Case Reports in Pediatrics No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1059771
American Medical Association (AMA)
Tong, Hoi Y.& Díaz, Carmen& Collantes, Elena& Medrano, Nicolás& Borobia, Alberto M.& Jara, Paloma…[et al.]. Liver Transplant in a Patient under Methylphenidate Therapy: A Case Report and Review of the Literature. Case Reports in Pediatrics. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059771
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059771