Serum Creatinine Level: A Supplemental Index to Distinguish Duchenne Muscular Dystrophy from Becker Muscular Dystrophy

المؤلفون المشاركون

Zhang, Huili
Zhu, Yuling
Sun, Yiming
Liang, Yingyin
Li, Yaqin
Zhang, Yu
Deng, Langhui
Wen, Xingxuan
Zhang, Cheng

المصدر

Disease Markers

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-03-17

دولة النشر

مصر

عدد الصفحات

5

التخصصات الرئيسية

الأمراض

الملخص EN

Background.

To improve assessment of dystrophinopathy, the aim of this study was to identify whether serum creatinine (Crn) level reflects disease severity.

Methods.

Biochemical, Vignos score, and genetic data were collected on 212 boys with dystrophinopathy.

Results.

Serum Crn level had a strong inverse correlation with Vignos score by simple correlation ( r = - 0.793 ) and partial correlation analysis after adjustment for age, height, and weight ( r = - 0.791 ; both P < 0.01 ).

Serum Crn level was significantly higher in patients with in-frame than out-of-frame mutations ( Z = - 4.716 , P < 0.01 ) and in Becker muscular dystrophy (BMD) patients than Duchenne muscular dystrophy (DMD) patients at ages 4, 5, 7, and 9 yr (all P < 0.0125 ).

After adjusting for age, height, and weight, BMD patients still had a significantly higher serum Crn level than DMD patients ( β = 7.140 , t = 6.277 , P < 0.01 ) .

Conclusions.

Serum Crn level reflected disease severity and may serve as a supplemental index to distinguish DMD from BMD in clinical practice.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zhang, Huili& Zhu, Yuling& Sun, Yiming& Liang, Yingyin& Li, Yaqin& Zhang, Yu…[et al.]. 2015. Serum Creatinine Level: A Supplemental Index to Distinguish Duchenne Muscular Dystrophy from Becker Muscular Dystrophy. Disease Markers،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1060859

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zhang, Huili…[et al.]. Serum Creatinine Level: A Supplemental Index to Distinguish Duchenne Muscular Dystrophy from Becker Muscular Dystrophy. Disease Markers No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1060859

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zhang, Huili& Zhu, Yuling& Sun, Yiming& Liang, Yingyin& Li, Yaqin& Zhang, Yu…[et al.]. Serum Creatinine Level: A Supplemental Index to Distinguish Duchenne Muscular Dystrophy from Becker Muscular Dystrophy. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1060859

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1060859