Serum Creatinine Level: A Supplemental Index to Distinguish Duchenne Muscular Dystrophy from Becker Muscular Dystrophy
Joint Authors
Zhang, Huili
Zhu, Yuling
Sun, Yiming
Liang, Yingyin
Li, Yaqin
Zhang, Yu
Deng, Langhui
Wen, Xingxuan
Zhang, Cheng
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-17
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
To improve assessment of dystrophinopathy, the aim of this study was to identify whether serum creatinine (Crn) level reflects disease severity.
Methods.
Biochemical, Vignos score, and genetic data were collected on 212 boys with dystrophinopathy.
Results.
Serum Crn level had a strong inverse correlation with Vignos score by simple correlation ( r = - 0.793 ) and partial correlation analysis after adjustment for age, height, and weight ( r = - 0.791 ; both P < 0.01 ).
Serum Crn level was significantly higher in patients with in-frame than out-of-frame mutations ( Z = - 4.716 , P < 0.01 ) and in Becker muscular dystrophy (BMD) patients than Duchenne muscular dystrophy (DMD) patients at ages 4, 5, 7, and 9 yr (all P < 0.0125 ).
After adjusting for age, height, and weight, BMD patients still had a significantly higher serum Crn level than DMD patients ( β = 7.140 , t = 6.277 , P < 0.01 ) .
Conclusions.
Serum Crn level reflected disease severity and may serve as a supplemental index to distinguish DMD from BMD in clinical practice.
American Psychological Association (APA)
Zhang, Huili& Zhu, Yuling& Sun, Yiming& Liang, Yingyin& Li, Yaqin& Zhang, Yu…[et al.]. 2015. Serum Creatinine Level: A Supplemental Index to Distinguish Duchenne Muscular Dystrophy from Becker Muscular Dystrophy. Disease Markers،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1060859
Modern Language Association (MLA)
Zhang, Huili…[et al.]. Serum Creatinine Level: A Supplemental Index to Distinguish Duchenne Muscular Dystrophy from Becker Muscular Dystrophy. Disease Markers No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1060859
American Medical Association (AMA)
Zhang, Huili& Zhu, Yuling& Sun, Yiming& Liang, Yingyin& Li, Yaqin& Zhang, Yu…[et al.]. Serum Creatinine Level: A Supplemental Index to Distinguish Duchenne Muscular Dystrophy from Becker Muscular Dystrophy. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1060859
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060859