![](/images/graphics-bg.png)
Vascular Effects of Advanced Glycation End-Products: Content of Immunohistochemically Detected AGEs in Radial Artery Samples as a Predictor for Arterial Calcification and Cardiovascular Risk in Asymptomatic Patients with Chronic Kidney Disease
المؤلفون المشاركون
Krzanowski, Marcin
Litwin, Jan A.
Gajda, Mariusz
Jasek, Ewa
Pietrzycka, Agata
Kuźniewski, Marek
Sułowicz, Władysław
Janda, Katarzyna
Dumnicka, Paulina
Fedak, Danuta
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-17
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objectives.
Our aim was to determine whether vascular deposition of advanced glycation end-products (AGEs) is associated with arterial calcification and cardiovascular mortality in chronic kidney disease (CKD) patients and to assess the relationships between vascular content of AGEs and selected clinical and biochemical parameters.
Materials and Methods.
The study comprised 54 CKD patients (33 hemodialyzed, 21 predialyzed).
Examined parameters included BMI, incidence of diabetes, plasma fasting glucose, AGEs, soluble receptor for AGEs and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging, serum C-reactive protein (hsCRP), plasminogen activator inhibitor-1 (PAI-1), and fetuin-A.
Fragments of radial artery obtained during creation of hemodialysis access were stained for calcifications using alizarin red.
AGEs deposits were identified immunohistochemically and their relative content was quantified.
Results.
Vascular content of AGEs was positively correlated with BMI, hsCRP, fetuin-A, PAI-1, and DPPH scavenging in simple regression; only fetuin-A was an independent predictor in multiple regression.
There was a significant positive trend in the intensity of AGEs immunostaining among patients with grades 1, 2, and 3 calcifications.
AGEs immunostaining intensity predicted 3-year cardiovascular mortality irrespective of patient’s age.
Conclusions.
The present study demonstrates an involvement of AGEs in the development of medial arterial calcification and the impact of arterial AGE deposition on cardiovascular mortality in CKD patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Janda, Katarzyna& Krzanowski, Marcin& Gajda, Mariusz& Dumnicka, Paulina& Jasek, Ewa& Fedak, Danuta…[et al.]. 2015. Vascular Effects of Advanced Glycation End-Products: Content of Immunohistochemically Detected AGEs in Radial Artery Samples as a Predictor for Arterial Calcification and Cardiovascular Risk in Asymptomatic Patients with Chronic Kidney Disease. Disease Markers،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1060860
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Janda, Katarzyna…[et al.]. Vascular Effects of Advanced Glycation End-Products: Content of Immunohistochemically Detected AGEs in Radial Artery Samples as a Predictor for Arterial Calcification and Cardiovascular Risk in Asymptomatic Patients with Chronic Kidney Disease. Disease Markers No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1060860
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Janda, Katarzyna& Krzanowski, Marcin& Gajda, Mariusz& Dumnicka, Paulina& Jasek, Ewa& Fedak, Danuta…[et al.]. Vascular Effects of Advanced Glycation End-Products: Content of Immunohistochemically Detected AGEs in Radial Artery Samples as a Predictor for Arterial Calcification and Cardiovascular Risk in Asymptomatic Patients with Chronic Kidney Disease. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1060860
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1060860
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)