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Vascular Effects of Advanced Glycation End-Products: Content of Immunohistochemically Detected AGEs in Radial Artery Samples as a Predictor for Arterial Calcification and Cardiovascular Risk in Asymptomatic Patients with Chronic Kidney Disease
Joint Authors
Krzanowski, Marcin
Litwin, Jan A.
Gajda, Mariusz
Jasek, Ewa
Pietrzycka, Agata
Kuźniewski, Marek
Sułowicz, Władysław
Janda, Katarzyna
Dumnicka, Paulina
Fedak, Danuta
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objectives.
Our aim was to determine whether vascular deposition of advanced glycation end-products (AGEs) is associated with arterial calcification and cardiovascular mortality in chronic kidney disease (CKD) patients and to assess the relationships between vascular content of AGEs and selected clinical and biochemical parameters.
Materials and Methods.
The study comprised 54 CKD patients (33 hemodialyzed, 21 predialyzed).
Examined parameters included BMI, incidence of diabetes, plasma fasting glucose, AGEs, soluble receptor for AGEs and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging, serum C-reactive protein (hsCRP), plasminogen activator inhibitor-1 (PAI-1), and fetuin-A.
Fragments of radial artery obtained during creation of hemodialysis access were stained for calcifications using alizarin red.
AGEs deposits were identified immunohistochemically and their relative content was quantified.
Results.
Vascular content of AGEs was positively correlated with BMI, hsCRP, fetuin-A, PAI-1, and DPPH scavenging in simple regression; only fetuin-A was an independent predictor in multiple regression.
There was a significant positive trend in the intensity of AGEs immunostaining among patients with grades 1, 2, and 3 calcifications.
AGEs immunostaining intensity predicted 3-year cardiovascular mortality irrespective of patient’s age.
Conclusions.
The present study demonstrates an involvement of AGEs in the development of medial arterial calcification and the impact of arterial AGE deposition on cardiovascular mortality in CKD patients.
American Psychological Association (APA)
Janda, Katarzyna& Krzanowski, Marcin& Gajda, Mariusz& Dumnicka, Paulina& Jasek, Ewa& Fedak, Danuta…[et al.]. 2015. Vascular Effects of Advanced Glycation End-Products: Content of Immunohistochemically Detected AGEs in Radial Artery Samples as a Predictor for Arterial Calcification and Cardiovascular Risk in Asymptomatic Patients with Chronic Kidney Disease. Disease Markers،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1060860
Modern Language Association (MLA)
Janda, Katarzyna…[et al.]. Vascular Effects of Advanced Glycation End-Products: Content of Immunohistochemically Detected AGEs in Radial Artery Samples as a Predictor for Arterial Calcification and Cardiovascular Risk in Asymptomatic Patients with Chronic Kidney Disease. Disease Markers No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1060860
American Medical Association (AMA)
Janda, Katarzyna& Krzanowski, Marcin& Gajda, Mariusz& Dumnicka, Paulina& Jasek, Ewa& Fedak, Danuta…[et al.]. Vascular Effects of Advanced Glycation End-Products: Content of Immunohistochemically Detected AGEs in Radial Artery Samples as a Predictor for Arterial Calcification and Cardiovascular Risk in Asymptomatic Patients with Chronic Kidney Disease. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1060860
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060860