Association of High Expression of Groβ with Clinical and Pathological Characteristics of Unfavorable Prognosis in Gastrointestinal Stromal Tumors
المؤلفون المشاركون
Zhu, Huijun
Zhao, Hui
Jin, Qin
Zhang, Shu
Wang, Wei
Wang, Defeng
Huang, Jianfei
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-07
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
GROβ (CXCL2) is a chemokine produced by endotoxin-treated macrophages that mediates inflammation and tumor development.
However, little is known about GROβ expression in gastrointestinal stromal tumors (GIST) or the relationship between GROβ expression and clinical attributes of GIST.
GROβ expression was examined via immunohistochemical staining of 173 GIST samples using tissue microarray.
The relationship between GROβ expression and relevant patient and tumor characteristics was assessed, using chi-square tests.
Univariate and multivariate analysis was carried out using the Cox regression method.
High GROβ cytoplasm staining was detected in 56 (32.4%) specimens; high GROβ nuclear staining was detected in 64 (37.0%) specimens.
High GROβ cytoplasm staining was significantly associated with patients’ age (P=0.043) and tumor location (P=0.014), while high GROβ nucleus staining was significantly associated with mitotic index (P=0.034), tumor location (P=0.049), and AFIP-Miettinen risk classification (P=0.048).
Kaplan-Meier survival curves showed GIST patients with low GROβ cytoplasm expression (P=0.023) and mitotic index < 6 per 50 HPFs (P=0.026) to have a more favorable prognosis.
These findings indicate that GROβ expression correlates with malignant GIST phenotypes and could be an unfavorable prognostic marker in patients with GIST.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Hui& Zhu, Huijun& Jin, Qin& Zhang, Shu& Wang, Wei& Wang, Defeng…[et al.]. 2015. Association of High Expression of Groβ with Clinical and Pathological Characteristics of Unfavorable Prognosis in Gastrointestinal Stromal Tumors. Disease Markers،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060868
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Hui…[et al.]. Association of High Expression of Groβ with Clinical and Pathological Characteristics of Unfavorable Prognosis in Gastrointestinal Stromal Tumors. Disease Markers No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1060868
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Hui& Zhu, Huijun& Jin, Qin& Zhang, Shu& Wang, Wei& Wang, Defeng…[et al.]. Association of High Expression of Groβ with Clinical and Pathological Characteristics of Unfavorable Prognosis in Gastrointestinal Stromal Tumors. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060868
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1060868
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر