Association of High Expression of Groβ with Clinical and Pathological Characteristics of Unfavorable Prognosis in Gastrointestinal Stromal Tumors
Joint Authors
Zhu, Huijun
Zhao, Hui
Jin, Qin
Zhang, Shu
Wang, Wei
Wang, Defeng
Huang, Jianfei
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
GROβ (CXCL2) is a chemokine produced by endotoxin-treated macrophages that mediates inflammation and tumor development.
However, little is known about GROβ expression in gastrointestinal stromal tumors (GIST) or the relationship between GROβ expression and clinical attributes of GIST.
GROβ expression was examined via immunohistochemical staining of 173 GIST samples using tissue microarray.
The relationship between GROβ expression and relevant patient and tumor characteristics was assessed, using chi-square tests.
Univariate and multivariate analysis was carried out using the Cox regression method.
High GROβ cytoplasm staining was detected in 56 (32.4%) specimens; high GROβ nuclear staining was detected in 64 (37.0%) specimens.
High GROβ cytoplasm staining was significantly associated with patients’ age (P=0.043) and tumor location (P=0.014), while high GROβ nucleus staining was significantly associated with mitotic index (P=0.034), tumor location (P=0.049), and AFIP-Miettinen risk classification (P=0.048).
Kaplan-Meier survival curves showed GIST patients with low GROβ cytoplasm expression (P=0.023) and mitotic index < 6 per 50 HPFs (P=0.026) to have a more favorable prognosis.
These findings indicate that GROβ expression correlates with malignant GIST phenotypes and could be an unfavorable prognostic marker in patients with GIST.
American Psychological Association (APA)
Zhao, Hui& Zhu, Huijun& Jin, Qin& Zhang, Shu& Wang, Wei& Wang, Defeng…[et al.]. 2015. Association of High Expression of Groβ with Clinical and Pathological Characteristics of Unfavorable Prognosis in Gastrointestinal Stromal Tumors. Disease Markers،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060868
Modern Language Association (MLA)
Zhao, Hui…[et al.]. Association of High Expression of Groβ with Clinical and Pathological Characteristics of Unfavorable Prognosis in Gastrointestinal Stromal Tumors. Disease Markers No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1060868
American Medical Association (AMA)
Zhao, Hui& Zhu, Huijun& Jin, Qin& Zhang, Shu& Wang, Wei& Wang, Defeng…[et al.]. Association of High Expression of Groβ with Clinical and Pathological Characteristics of Unfavorable Prognosis in Gastrointestinal Stromal Tumors. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060868
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060868