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Blockade of Aquaporin 1 Inhibits Proliferation, Motility, and Metastatic Potential of Mesothelioma In Vitro but not in an In Vivo Model
المؤلفون المشاركون
Klebe, Sonja
Griggs, Kim
Cheng, Yuen
Driml, Jack
Henderson, Douglas W.
Reid, Glen
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-04
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Malignant mesothelioma (MM) is an aggressive tumor of the serosal membranes, mostly the pleura.
It is related to asbestos exposure and has a poor prognosis.
MM has a long latency period, and incidence is predicted to remain stable or increase until 2020.
Currently, no biomarkers for a specific targeted therapy are available.
Previously, we observed that expression of aquaporin 1 (AQP1) was an indicator of prognosis in two independent cohorts.
Here we determine whether AQP1 inhibition has therapeutic potential in the treatment of MM.
Methods.
Functional studies were performed with H226 cells and primary MM cells harvested from pleural effusions.
AQP1 expression and mesothelial phenotype was determined by immunohistochemistry.
AQP1 function was inhibited by a pharmacological blocker (AqB050) or AQP1-specific siRNA.
Cell proliferation, migration, and anchorage-independent cell growth were assessed.
A nude mouse heterotopic xenograft model of MM was utilised for the in vivo studies.
Results.
Inhibition of AQP1 significantly decreases cell proliferation, metastatic potential, and motility without inducing nonspecific cytotoxicity or increasing apoptosis.
In vivo blockade of AQP1 had no biologically significant effect on growth of established tumours.
Conclusions.
Targeted blockade of AQP1 restricts MM growth and migration in vitro.
Further work is warranted to fully evaluate treatment potential in vivo.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Klebe, Sonja& Griggs, Kim& Cheng, Yuen& Driml, Jack& Henderson, Douglas W.& Reid, Glen. 2015. Blockade of Aquaporin 1 Inhibits Proliferation, Motility, and Metastatic Potential of Mesothelioma In Vitro but not in an In Vivo Model. Disease Markers،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1060897
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Klebe, Sonja…[et al.]. Blockade of Aquaporin 1 Inhibits Proliferation, Motility, and Metastatic Potential of Mesothelioma In Vitro but not in an In Vivo Model. Disease Markers No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1060897
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Klebe, Sonja& Griggs, Kim& Cheng, Yuen& Driml, Jack& Henderson, Douglas W.& Reid, Glen. Blockade of Aquaporin 1 Inhibits Proliferation, Motility, and Metastatic Potential of Mesothelioma In Vitro but not in an In Vivo Model. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1060897
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1060897
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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