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Immunohistochemical Expression of Survivin and Its Relationship with Cell Apoptosis and Proliferation in Ameloblastomas
المؤلفون المشاركون
González-González, Rogelio
Molina-Frechero, Nelly
Damian-Matsumura, Pablo
Salazar-Rodriguez, Sirced
Bologna-Molina, Ronell
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-18
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Ameloblastoma behavior is related to the potential of tumor cells to inhibit apoptosis and to initiate a proliferative phase.
This study was performed to compare the immunoexpression of Survivin with Bcl-2, Bax, and Ki-67 and to associate them with the histopathological type of each variant of ameloblastoma.
Material and Methods.
Using the World Health Organization (WHO) criteria for ameloblastoma, 110 cases were selected.
The cases were classified as solid/multicystic and unicystic ameloblastomas.
Cellular counts of cytoplasmic immunoexpression were assessed for cytoplasmic Survivin, Bcl-2, and Bax, while the nuclear immunoexpression of Survivin and Ki-67 was assessed using label index.
Results.
Cytoplasmic Survivin and Bcl-2 showed higher percentages of immunoexpression in solid multicystic ameloblastomas compared to unicystic ameloblastomas (P<0.05).
Bax, Ki-67, and nuclear Survivin were expressed in higher percentages in unicystic ameloblastomas.
Conclusions.
Cytoplasmic Survivin and Bcl-2 immunoexpression levels were elevated in relation to Bax immunoexpression, suggesting aggressive ameloblastoma behavior, while Ki-67 and nuclear Survivin immunoexpression may be associated with the type of tumor morphology that influences cellular counts or with the greater capacity for cellular proliferation and tumor growth.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
González-González, Rogelio& Molina-Frechero, Nelly& Damian-Matsumura, Pablo& Salazar-Rodriguez, Sirced& Bologna-Molina, Ronell. 2015. Immunohistochemical Expression of Survivin and Its Relationship with Cell Apoptosis and Proliferation in Ameloblastomas. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060900
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
González-González, Rogelio…[et al.]. Immunohistochemical Expression of Survivin and Its Relationship with Cell Apoptosis and Proliferation in Ameloblastomas. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1060900
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
González-González, Rogelio& Molina-Frechero, Nelly& Damian-Matsumura, Pablo& Salazar-Rodriguez, Sirced& Bologna-Molina, Ronell. Immunohistochemical Expression of Survivin and Its Relationship with Cell Apoptosis and Proliferation in Ameloblastomas. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060900
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1060900
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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