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Immunohistochemical Expression of Survivin and Its Relationship with Cell Apoptosis and Proliferation in Ameloblastomas
Joint Authors
González-González, Rogelio
Molina-Frechero, Nelly
Damian-Matsumura, Pablo
Salazar-Rodriguez, Sirced
Bologna-Molina, Ronell
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Ameloblastoma behavior is related to the potential of tumor cells to inhibit apoptosis and to initiate a proliferative phase.
This study was performed to compare the immunoexpression of Survivin with Bcl-2, Bax, and Ki-67 and to associate them with the histopathological type of each variant of ameloblastoma.
Material and Methods.
Using the World Health Organization (WHO) criteria for ameloblastoma, 110 cases were selected.
The cases were classified as solid/multicystic and unicystic ameloblastomas.
Cellular counts of cytoplasmic immunoexpression were assessed for cytoplasmic Survivin, Bcl-2, and Bax, while the nuclear immunoexpression of Survivin and Ki-67 was assessed using label index.
Results.
Cytoplasmic Survivin and Bcl-2 showed higher percentages of immunoexpression in solid multicystic ameloblastomas compared to unicystic ameloblastomas (P<0.05).
Bax, Ki-67, and nuclear Survivin were expressed in higher percentages in unicystic ameloblastomas.
Conclusions.
Cytoplasmic Survivin and Bcl-2 immunoexpression levels were elevated in relation to Bax immunoexpression, suggesting aggressive ameloblastoma behavior, while Ki-67 and nuclear Survivin immunoexpression may be associated with the type of tumor morphology that influences cellular counts or with the greater capacity for cellular proliferation and tumor growth.
American Psychological Association (APA)
González-González, Rogelio& Molina-Frechero, Nelly& Damian-Matsumura, Pablo& Salazar-Rodriguez, Sirced& Bologna-Molina, Ronell. 2015. Immunohistochemical Expression of Survivin and Its Relationship with Cell Apoptosis and Proliferation in Ameloblastomas. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060900
Modern Language Association (MLA)
González-González, Rogelio…[et al.]. Immunohistochemical Expression of Survivin and Its Relationship with Cell Apoptosis and Proliferation in Ameloblastomas. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1060900
American Medical Association (AMA)
González-González, Rogelio& Molina-Frechero, Nelly& Damian-Matsumura, Pablo& Salazar-Rodriguez, Sirced& Bologna-Molina, Ronell. Immunohistochemical Expression of Survivin and Its Relationship with Cell Apoptosis and Proliferation in Ameloblastomas. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060900
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060900